IRCT20211029052903N1 IRCT 2023-01-17 Esfahan University of Medical Sciences Evaluation of the effect of Memantine in patients with brain tumors The effect of Memantine on cognitive impairment in patients with brain tumor under radiotherapy 2022-01-21 anticipated 70 Complete https://irct.ir/trial/59730 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization of patients in two groups is done by simple random method. In this method, the letter I is written on 35 cards and the letter C is written on 35 sheets. All cards are placed in a box and mixed well. When each person enters the study, a card is taken out of the box. According to the letter recorded on the sheet, the patient is assigned to one of the two groups I (intervention) and C (control), Blinding description: Patients and the outcome assessor are unaware of the type of medication they are receiving. The medicine and placebo are prepared in similar and coded packages and are given to the patients by the research doctor, but the person who evaluates the outcome of the treatment is unaware of the type of medicine received. 3 Cognitive Impairment. Intervention 1: Intervention group: Daily intake of two 5 mg memantine tablets 12 hours after a meal for 6 weeks. Intervention 2: Control group: Receiver of a placebo pill similar to Memantine at the same dose and time as the intervention group. No - There is not a plan to make this available Justification or reason for not sharing IPD is The plan belongs to a government agency and cannot be shared