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IRCT20211102052949N1 IRCT 2021-12-20 Gonabad University of Medical Sciences Salicylic acid in acne vulgaris Comparison of the effect of 40% salicylic acid versus 30% salicylic acid with and without combination with doxycycline in the treatment of moderate acne vulgaris: a double-blinded, randomized, clinical trial 2021-11-29 anticipated 99 Complete https://irct.ir/trial/59770 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: At first, people who have the Word criterion to study, after obtaining the consent of the company to study based on the selected goal, then people will be divided into three groups of intervention 1, 2 and control in the form of glass permutation blocks, Blinding description: In this study, patients and analysts will be unaware of the allocation of individuals to treatment groups. Prior to sampling, participants will be asked not to confuse the treatment method with other people, and also to note the treatment for individuals so that the samples have the least contact with each other. 1 Acne vulgaris. Intervention 1: Intervention group:Intervention group: Patients are first examined by a dermatologist to measure the severity of their acne based on Michelson's acne score, and patients undergo standard photography. Then (recipients of 30% salicylic acid and doxycycline) treatment for 12 weeks with doxycycline 100 mg daily and peeling 30% salicylic acid will be done every two weeks. Then, once every two weeks until the end of treatment and also one month after the end of treatment, acne severity will be assessed based on Michelson's acne score, patient satisfaction, improvement based on the doctor's opinion and examination based on photography. Intervention 2: IPatients are first examined by a dermatologist to measure the severity of their acne based on Michelson's acne score, and patients undergo standard photography. Then (recipients of 40% salicylic acid and doxycycline placebo) treatment for 12 weeks with daily doxycycline placebo and 40% salicylic acid peeling will be performed every two weeks. Then, once every two weeks until the end of treatment and also one month after the end of treatment, acne severity will be assessed based on Michelson's acne score, patient satisfaction, improvement based on the doctor's opinion and examination based on photography. Intervention 3: Control group: Control group: At first, patients are examined by a dermatologist. The severity of their acne is measured based on Michelson's acne score and patients undergo standard photography. Then (recipients of 30% salicylic acid and doxycycline placebo) treatment for 12 weeks with doxycycline placebo Daily and 30% salicylic acid peeling will do once every two weeks. Then, once every two weeks until the end of treatment and also one month after the end of treatment, acne severity will be assessed based on Michelson's acne score, patient satisfaction, improvement based on the doctor's opinion and examination based on photography. Yes - There is a plan to make this available What will be shared: All data will be provided to researchers without names and details. When: After completing the design and printing of the article To whom: All researchers and pharmaceutical companies Conditions: For similar research, the officials of pharmaceutical companies can access the results of the project by referring to the research vice chancellor of Gonabad University of Medical Sciences with the written consent of the vice chancellor for research. Where to obtain: Vice Chancellor for Research, Gonabad University of Medical Sciences How to obtain: Researchers can access the results of the project by referring to the Vice Chancellor for Research of Gonabad University of Medical Sciences with the written consent of the Vice Chancellor for Research. Comments:
public Hamideh Mohammadzadeh
Bohlol Hospital, Parastar Boulevard, Gonabad Town
Gonabad Iran (Islamic Republic of) ۹۷۸۵۲_۹۶۹۱۷ +98 51 5723 6832 Mohammadzadeh.hamideh@yahoo.com Gonabad University of Medical Sciences scientific Hamideh mohammadzadeh
Bohlol Hospital, Parastar Boulevard, Gonabad Town
Gonabad Iran (Islamic Republic of) ۹۷۸۵۲_۹۶۹۱۷ +98 51 5723 6832 Mohammadzadeh.hamideh@yahoo.com Gonabad University of Medical Sciences Iran (Islamic Republic of) Moderate acne vulgaris(according to Vaishampayan classification) Age greater than 12 years 12 years 40 years Both Pregnancy or intending to Breastfeeding Taking oral and topical acne medications in the last 34 day History of allergies to the drugs used in the study History of light sensitivity Existence of recurrent herpes simplex infection Presence of warts on the face and contagious molluscum in patients Active dermatitis on the face Having gastrointestinal disorders (especially esophagitis and gastroesophageal reflux) History of liver and kidney diseases Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group:Intervention group: Patients are first examined by a dermatologist to measure the severity of their acne based on Michelson's acne score, and patients undergo standard photography. Then (recipients of 30% salicylic acid and doxycycline) treatment for 12 weeks with doxycycline 100 mg daily and peeling 30% salicylic acid will be done every two weeks. Then, once every two weeks until the end of treatment and also one month after the end of treatment, acne severity will be assessed based on Michelson's acne score, patient satisfaction, improvement based on the doctor's opinion and examination based on photography. IPatients are first examined by a dermatologist to measure the severity of their acne based on Michelson's acne score, and patients undergo standard photography. Then (recipients of 40% salicylic acid and doxycycline placebo) treatment for 12 weeks with daily doxycycline placebo and 40% salicylic acid peeling will be performed every two weeks. Then, once every two weeks until the end of treatment and also one month after the end of treatment, acne severity will be assessed based on Michelson's acne score, patient satisfaction, improvement based on the doctor's opinion and examination based on photography. Control group: Control group: At first, patients are examined by a dermatologist. The severity of their acne is measured based on Michelson's acne score and patients undergo standard photography. Then (recipients of 30% salicylic acid and doxycycline placebo) treatment for 12 weeks with doxycycline placebo Daily and 30% salicylic acid peeling will do once every two weeks. Then, once every two weeks until the end of treatment and also one month after the end of treatment, acne severity will be assessed based on Michelson's acne score, patient satisfaction, improvement based on the doctor's opinion and examination based on photography. Acne vulgaris. Timepoint: Observation of the number and type of facial acne vulgaris before the intervention and 12 weeks after the intervention and also one month after the intervention. Method of measurement: system Vaishampayan, Standard Photography, Michelson Acne Score. Gonabad University of Medical Sciences Approved 2021-02-06 Ethics Committee of Gonabad University of Medical Sciences Khorasan Razavi, Gonabad, Imam Khomeini St., Gonabad University of Medical Sciences Gonabad Razavi Khorasan Iran (Islamic Republic of)