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IRCT20211101052931N1 IRCT 2021-12-02 Semnan University of Medical Sciences Comparison of the Effects of Ketorolac and Lidocaine on Reducing Pain of Propofol with or without tourniquet Comparison of the Effects of Ketorolac and Lidocaine on Reducing Pain During Propofol IV Injection in general anesthesia induction with or without tourniquet 2021-11-22 anticipated 120 Complete https://irct.ir/trial/59821 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization (quadruple blocks) All possible blocks are arranged as follows: block 1: ABAB block 2: AABB block 3: ABBA block 4: BBAA block 5: BABA block 6: BAAB We need 30 blocks to select 120 people. We randomly select these blocks from the numbers 1 to 6.Using R software, we choose a random number between the numbers 1 to 6. For example, number 6 is chosen as the first block and number 2 as the forth block. The people who enter the study are given B-A-A-BA- A-B-B, respectively. Finally, group 1 and group 2 will be identified. 3 Each patient is a candidate for elective surgery who uses Propofol for anesthesia.(Comparison of the Effects of Ketorolac and Lidocaine on Reducing Pain During Propofol IV Injection with or without tourniquet in general anesthesia induction ). Intervention 1: L1: Injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 40 mg Lidocaine. Intervention 2: L2: Injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 40 mg Lidocaine with tourniquet. Intervention 3: K1: Injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 10 mg Ketorolac. Intervention 4: K2: Injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 10 mg Ketorolac with tourniquet. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I have not decided yet. Release schedule is unknown.
public Abolfazl Abdollahpoor
Semnan University of Medical Sciences
Semnan Iran (Islamic Republic of) 3519899951 +98 23 3344 1022 kosarhos@semums.ac.ir Semnan University of Medical Sciences scientific Abolfazl Abdollahpoor
Semnan University Of Medical Sciences
Semnan Iran (Islamic Republic of) 3519899951 +98 23 3344 1022 felordce@yahoo.com Semnan University of Medical Sciences Iran (Islamic Republic of) Patients must be in the American Society of Anesthesiology or ASA Class 1 and 2 . Have the ability to communicate verbally. no limit no limit Both People who are pregnant. Patients with a history of hypnotic, narcotic, or analgesic use in the 24 hours before the surgery or have a history of drug, analgesic, or alcohol dependence Patients who are prohibited from taking Propofol (including allergies to foods such as eggs, soybeans, and Propofol), prohibition of lidocaine or ketorolac, or other nonsteroidal anti-inflammatory drugs (NSAIDs). Patients with chronic pain syndromes, neurological or psychological diseases. Patients who become allergic to drugs during the test. Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs L1: Injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 40 mg Lidocaine L2: Injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 40 mg Lidocaine with tourniquet K1: Injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 10 mg Ketorolac K2: Injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 10 mg Ketorolac with tourniquet Pain score in VRS questionnaire. Timepoint: Immediately after intravenous injection of a quarter of Propofol in induction of anesthesia. Method of measurement: Pain intensity is assessed according to the Verbal Rating Scale(VRS). Semnan University of Medical Sciences Approved 2021-10-31 Semnan University of Medical Sciences - Research and development Vice Semnan University of Medical Sciences Semnan Semnan Iran (Islamic Republic of)