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IRCT20211101052932N1 IRCT 2022-02-12 Semnan University of Medical Sciences Comparison of the Effects of Metoclopramide and Lidocaine on Reducing Pain of Propofol with or without tourniquet Comparison of the Effects of Metoclopramide and Lidocaine on Reducing Pain During Propofol IV Injection in general anesthesia induction with or without tourniquet , Kosar hospital , Semnan ,2021 2021-11-22 anticipated 120 Complete https://irct.ir/trial/59823 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: no, Randomization description: There are two drugs in total (A B), each in two states with and without tourniquets (0 and 1), which can be 4 general cases with these names: A0 A1 B0 B1 These names were introduced to the software and the software was run to assign equal samples to each group. The output list of the software will be the criterion for action. https://www.random.org/lists/ For random assignment to 4 groups, the names of each group up to 30 (each item in a row) were entered in the software box and executed in the software. In this way, the software has separate boxes In the first box 30 times A0 In the second box 30 times A1 In the third box 30 times B0 B1 is placed in the fourth box 30 times The software has a key that by hitting it, the software itself randomizes the data. 3 Each patient is a candidate for elective surgery who uses Propofol for anesthesia.(Comparison of the Effects of Metoclopramide and Lidocaine on Reducing Pain During Propofol IV Injection with or without tourniquet in general anesthesia induction ). Intervention 1: Group L1: injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 40 mg Lidocaine. Intervention 2: Group L2: injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 40 mg lidocaine by using the tourniquet. Intervention 3: M1: injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 10 mg Metoclopramide. Intervention 4: Group M2: injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 10 mg metoclopramide by using the tourniquet. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I have not decided yet. Release schedule unknown.
public Abolfazl Abdollahpour
Semnan University of Medical Sciences
Semnan Iran (Islamic Republic of) 3519899951 +98 23 3344 1022 felordce@yahoo.com Semnan University of Medical Sciences scientific Parinaz Mirakhorli
Semnan University of Medical Sciences
Semnan Iran (Islamic Republic of) 3519899951 +98 23 3344 1022 info@semums.ac.ir Semnan University of Medical Sciences Iran (Islamic Republic of) Patients must be in the American Society of Anesthesiology or ASA Class 1 and 2 . Have the ability to communicate verbally. All patients undergoing elective surgery who require general anesthesia, regardless of the type of surgery and the individual's disease. no limit no limit Both People who are pregnant. Patients with a history of hypnotic, narcotic, or analgesic use in the 24 hours before the surgery or have a history of drug, analgesic, or alcohol dependence. Patients who are prohibited from taking Propofol (including allergies to foods such as eggs, soybeans, and Propofol), prohibition of lidocaine or metoclopramide, or other nonsteroidal anti-inflammatory drugs (NSAIDs). Patients with chronic pain syndromes, neurological or psychological diseases. Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Group L1: injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 40 mg Lidocaine Group L2: injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 40 mg lidocaine by using the tourniquet M1: injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 10 mg Metoclopramide Group M2: injection of 2 mg / kg Propofol at a rate of 0.5 cc per second after injection of 10 mg metoclopramide by using the tourniquet Pain score in VRS questionnaire. Timepoint: Immediately after intravenous injection of a quarter of Propofol in induction of anesthesia. Method of measurement: Pain intensity is assessed according to the Verbal Rating Scale(VRS). Semnan University of Medical Sciences Approved 2021-10-26 Semnan University of Medical Sciences - Research and development Vice Semnan University of Medical Sciences Semnan Semnan Iran (Islamic Republic of)