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IRCT20211104052964N1 IRCT 2022-05-14 Qazvin University of Medical Sciences Evaluation of effect of mouthwashes on Salivary PH level Evaluation of the effect of two mouthwashes: Tea tree oil _ Alvoevera and Chlorhexidine 0/2 % on Salivary PH level 2022-05-26 anticipated 20 Complete https://irct.ir/trial/59922 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Crossover, Purpose: Basic scienece, Randomization description: The 20 participants of the study are divided into two groups A and B using random allocation software using random block method. The size of each block is 2 and the total number of blocks is 10.Balanced random allocation method for participants in a randomized clinical trial study is used to evaluate the effect of two mouthwashes of tea tree oil and aloe vera and chlorhexidine on saliva pH. 3 salivary Ph. Intervention 1: First intervention group: participants rinse 5 milliliter of Irsha Tea Tree Oil _ Aloe Vera Mouthwash, which contains Poloxamer 407, Isopropyl myristate,Thymol, Sorbitol, Menthol, Eucalyptus, Tea Tree Oil, Aloe Vera , Xylitol, Authorized Cosmetic Essential Oil, Sorbate, Thymol , Sodium benzoate, Potassium sorbate, Citric acid, Cetylpyridinium chloride, Sodium fluoride, Color CL.42090, CL.19140 and Deionized water once in their mouth for 1 minute. After 72 hours of wash out, participants rinse 5 milliliter of Irsha chlorhexidine 0.2% mouthwash which contains chlorhexidine digluconate, xylitol, Cetylpyridinium chloride, menthol, citric acid, deionized water, polysorbate , color CL.16035 and color CL.17200- once in their mouth for 1 minute. Intervention 2: Second Intervention group: participants rinse 5 milliliter of Irsha chlorhexidine 0.2% mouthwash which contains chlorhexidine digluconate, xylitol, Cetylpyridinium chloride, menthol, citric acid, deionized water, polysorbate , color CL.16035 and color CL.17200- once in their mouth for 1 minute. After 72 hours of wash out, participants rinse 5 milliliter of Irsha Tea Tree Oil _ Aloe Vera Mouthwash, which contains Poloxamer 407, Isopropyl myristate,Thymol, Sorbitol, Menthol, Eucalyptus, Tea Tree Oil, Aloe Vera , Xylitol, Authorized Cosmetic Essential Oil, Sorbate, Thymol , Sodium benzoate, Potassium sorbate, Citric acid, Cetylpyridinium chloride, Sodium fluoride, Color CL.42090, CL.19140 and Deionized water once in their mouth for 1 minute. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Fatemeh Vahdat Bivarzani
First floor, number 5, Golbarg 6 alley, Rangin kaman street, 3rd area, mohammadiyeh
Qazvin Iran (Islamic Republic of) 3491941359 +98 28 3256 6445 f.vahdatbivarzani@qums.ac.ir Qazvin University of Medical Sciences scientific Fatemeh Vahdat Bivarzani
First floor, number 5, Golbarg 6 alley, Rangin kaman street, 3rd area, mohammadiyeh
Qazvin Iran (Islamic Republic of) 3491941359 +98 28 3256 6445 f.vahdatbivarzani@qums.ac.ir Qazvin University of Medical Sciences Iran (Islamic Republic of) Dentistry students of Qazvin University of Medical Sciences in the age range of 18-25 years 18 years 25 years Both Having systemic diseases affecting saliva such as diabetes, hypertension and thyroid diseases Smoking and drugs abuse Taking anticholinergic, antihypertensive, antidepressant drugs History of radiotherapy Using intraoral devices such as orthodontic appliance Treatment - Drugs Treatment - Drugs First intervention group: participants rinse 5 milliliter of Irsha Tea Tree Oil _ Aloe Vera Mouthwash, which contains Poloxamer 407, Isopropyl myristate,Thymol, Sorbitol, Menthol, Eucalyptus, Tea Tree Oil, Aloe Vera , Xylitol, Authorized Cosmetic Essential Oil, Sorbate, Thymol , Sodium benzoate, Potassium sorbate, Citric acid, Cetylpyridinium chloride, Sodium fluoride, Color CL.42090, CL.19140 and Deionized water once in their mouth for 1 minute. After 72 hours of wash out, participants rinse 5 milliliter of Irsha chlorhexidine 0.2% mouthwash which contains chlorhexidine digluconate, xylitol, Cetylpyridinium chloride, menthol, citric acid, deionized water, polysorbate , color CL.16035 and color CL.17200- once in their mouth for 1 minute. Second Intervention group: participants rinse 5 milliliter of Irsha chlorhexidine 0.2% mouthwash which contains chlorhexidine digluconate, xylitol, Cetylpyridinium chloride, menthol, citric acid, deionized water, polysorbate , color CL.16035 and color CL.17200- once in their mouth for 1 minute. After 72 hours of wash out, participants rinse 5 milliliter of Irsha Tea Tree Oil _ Aloe Vera Mouthwash, which contains Poloxamer 407, Isopropyl myristate,Thymol, Sorbitol, Menthol, Eucalyptus, Tea Tree Oil, Aloe Vera , Xylitol, Authorized Cosmetic Essential Oil, Sorbate, Thymol , Sodium benzoate, Potassium sorbate, Citric acid, Cetylpyridinium chloride, Sodium fluoride, Color CL.42090, CL.19140 and Deionized water once in their mouth for 1 minute. PH level of saliva. Timepoint: Saliva pH is measured at the beginning of the study and after orange juice and immediately and 20 minutes after using mouthwashes. Method of measurement: Digital PH Meter Device. Qazvin University of Medical Sciences Approved 2021-09-15 Ethics committee of Qazvin University of Medical Sciences Deputy of research and technology ,The first sub,Mavedat Alley, Shahid Beheshti Boulevard Qazvin Qazvin Iran (Islamic Republic of)