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IRCT20211112053046N1 IRCT 2021-11-25 Mashhad University of Medical Sciences Effect of zinc supplementationin diagnosed cases of 2019 novel coronavirus Effect of zinc supplementation in diagnosed cases of 2019 Novel Coronavirus (SARS-CoV-2); a randomized clinical trial 2021-11-17 anticipated 140 Complete https://irct.ir/trial/60042 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In order to create a balance in the number of samples assigned to each of the groups studied, individuals are randomly divided into two groups by blocking method: Accordingly, because we have two groups, the allocation is done in the form of AB, BA and after reaching To the desired volume, it is randomly determined whether group A or B is the intervention group or placebo.Each patient is randomly assigned to one of the two intervention or control groups. Randomization is done in such a way that the type of treatment (intervention group or control group) is placed in closed envelopes and then one envelope is randomly assigned to each patient, Blinding description: Double-blind study: In this type of study, both participants and researchers are not initially aware that the individual is in the control or intervention group, and neither participants nor researchers are aware of the allocation of medication or placebo to patients. N/A Covid_19. Intervention 1: Intervention group:50 mg zinc tablets as a single dose made by Alhawi company for 14 days daily with lunch. Intervention 2: Control group: Placebo tablets, 14 days, with lunch, slaughtered in the Department of Pharmacology, Mashhad University of Medical Sciences. No - There is not a plan to make this available Justification or reason for not sharing IPD is Patients' identities will be kept confidential and will not be published anywhere
public Dr. Seyedeh Zahra Lotfi
Azadi Square, Campus of Mashhad University of Medical Sciences, School of Medicine
Mashhad Iran (Islamic Republic of) 9177948546 +98 51 3800 2420 Lotfiz@mums.ac.ir Mashhad University of Medical Sciences scientific Dr. Seyedeh Zahra Lotfi
Azadi Square, Campus of Mashhad University of Medical Sciences, School of Medicine
Mashhad Iran (Islamic Republic of) 9177948546 +98 51 3800 2420 Lotfiz@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Diagnosis of COVID-19 infection is subject to the approval of a specialist Age 18 to 65 years 18 years 65 years Both addict Allergy to zinc Pregnancy and lactation Occurrence of special medical conditions History of AIDS and chronic lung disease History of corticosteroids and chemotherapy drugs in the past month Use of drugs that affect metabolism Use multivitamin supplements that are more than 10 mg per day U07.1 Use this code when COVID-19 has been confirmed by laboratory testing irrespective of severity of clinical signs or symptoms. Use additional code, if desired, to identify pneumonia or other manifestations Treatment - Drugs Treatment - Drugs Intervention group:50 mg zinc tablets as a single dose made by Alhawi company for 14 days daily with lunch Control group: Placebo tablets, 14 days, with lunch, slaughtered in the Department of Pharmacology, Mashhad University of Medical Sciences Level CRP. Timepoint: Measurement of reaction level _ thirty before the intervention and 14 days after starting zinc supplementation. Method of measurement: Enzyme-dependent immunosorbent assay kit. Level of neutrophil to lymphocyte ratio. Timepoint: Measurement of neutrophil to lymphocyte ratio level before intervention and 14 days after zinc supplementation. Method of measurement: Microscopic counting. Mashhad University of Medical Sciences Approved 2021-07-03 Ethics Committee of Mashhad University of Medical Sciences Azadi Square, Campus of Mashhad University of Medical Sciences, School of Medicine Mashhad Razavi Khorasan Iran (Islamic Republic of)