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IRCT20211117053086N1 IRCT 2022-01-18 Shahre-kord University of Medical Sciences Evaluation of the effect of oral Clonidine on reducing bleeding during hysterectomy Evaluation of the effect of oral Clonidine on reducing bleeding during hysterectomy 2021-11-22 anticipated 70 Complete https://irct.ir/trial/60090 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Subjects were selected by convenience sampling method and Random Allocation divided into two groups A and B using clonidine (0.2 mg) and placebo tablets, respectively using randomizer software (Fahmy Corporation, Randomizer 2016.6.0.56), Blinding description: Resident (during operation and gas counting) and statistical consultant are unaware of the type of grouping (intervention or control). 3 hysterectomy. Intervention 1: The first group will be prescribed routine surgical preparations and clonidine tablets 0.2 (mg) 90 minutes before entering the operating room. This medicine will be provided by a Tolid-Daroo company. Intervention 2: Control group: In the second group, routine procedures will be performed to prepare for surgery, and a placebo will be provided by Tolid-Daroo company. Placebo tablets will be given 90 minutes before surgery. No - There is not a plan to make this available Justification or reason for not sharing IPD is Information is kept confidential
public Bibi Fatemeh Alavi
Hajar hospital, Parastar st.
Shahrekord Iran (Islamic Republic of) 8816754633 +98 38 3222 8575 eslami@ualberta.ca Shahre-kord University of Medical Sciences scientific Bibi Fatemeh Alavi
Hajar hospital, Parastar st.
Shahrekord Iran (Islamic Republic of) 8816754633 +98 38 3222 8575 eslami@ualberta.ca Shahre-kord University of Medical Sciences Iran (Islamic Republic of) Patient informed consent No pregnancy and use of birth control pills Absence of systemic diseases and inherited or acquired coagulation disorders No history of ischemic heart disease No history of taking anticoagulants that affect bleeding No smoking and alcohol Known insensitivity to clonidine No history of repeated abdominal surgeries and the presence of abdominal adhesions 40 years 60 years Female Raynaud's syndrome porphyria Renal dysfunction Prevention Placebo The first group will be prescribed routine surgical preparations and clonidine tablets 0.2 (mg) 90 minutes before entering the operating room. This medicine will be provided by a Tolid-Daroo company. Control group: In the second group, routine procedures will be performed to prepare for surgery, and a placebo will be provided by Tolid-Daroo company. Placebo tablets will be given 90 minutes before surgery. Bleeding rate. Timepoint: Immediately after surgery. Method of measurement: Visual estimation scale: The number of normal gases impregnated in blood is multiplied by 10 ml and long gases by 50 ml and the result is added to the volume of suctioned blood. Since this volume is included in the volume of rinsing fluids in the surgical area; It also reduces the amount of fluid consumed and the result is equal to the amount of actual blood loss of the patient. Shahre-kord University of Medical Sciences Approved 2021-10-26 Ethics committee of Shahrekord University of Medical Sciences Vice Chancellor for Research and Technology, Building No. 2, University Headquarters,Kashani Blvd. Shahrekord Chahar-Mahal-va-Bakhtiari Iran (Islamic Republic of)