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IRCT20200326046861N2 IRCT 2022-05-14 University of Isfahan Effect of exercise on some serum factors in children with type 1 diabetes Comparison of the effect of resistance and aerobic training on the expression of microRNA-192 and serum levels of GLP-1, GABA, Pentraxin3 and HbA1c in children with type 1 diabetes 2022-07-06 anticipated 60 Complete https://irct.ir/trial/60626 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A type 1 diabetes. Intervention 1: Intervention group 1: It consists of a group of 15 members with a resistance exercise protocol (exercises at home, with minimal exercise equipment and involving different muscle groups in the body) which is performed for 8 weeks and 3 days a week for 1 hour. Subjects will not use any medications or dietary supplements during the eight weeks of exercise other than the medications prescribed by their physician. Intervention 2: Intervention group 2: It consists of a group of 15 members with aerobic exercise protocol (exercises at home, with minimal exercise equipment) which is performed for 8 weeks and 3 days a week for 1 hour. Subjects will not use any medications or dietary supplements during the eight weeks of exercise other than the medications prescribed by their physician. Yes - There is a plan to make this available What will be shared: All blood and physiological data of individuals can be shared after they were made anonymous. When: The start of the access period will be 6 months after the publication of the results. To whom: For researchers and scientific journals Conditions: Researchers and scientific journals can access the data if they make their reports in coordination with us and mention the names of the main authors of this study in their report. Where to obtain: Applicants can contact the corresponding or other authors via email. How to obtain: Applicants can submit their application via email. Information will be provided to them in case of authors’ agreement. Comments:
public Maryam Nazari
University of Isfahan, Azadi square, Isfahan
Isfehan Iran (Islamic Republic of) 8174673441 +98-313-7932003-7 m.nazari1320@yahoo.com University of Isfahan scientific Maryam Nazari
University of Isfahan, Azadi square, Isfahan
Isfahan Iran (Islamic Republic of) 8174673441 +98 31 3793 2571 m.nazari1320@yahoo.com University of Isfahan Iran (Islamic Republic of) Type 1 diabetes at least one year after diagnosis no limit 18 years Both Diseases that prevent people from participating in exercising activities. E08 Diabetes mellitus due to underlying condition Lifestyle Lifestyle Intervention group 1: It consists of a group of 15 members with a resistance exercise protocol (exercises at home, with minimal exercise equipment and involving different muscle groups in the body) which is performed for 8 weeks and 3 days a week for 1 hour. Subjects will not use any medications or dietary supplements during the eight weeks of exercise other than the medications prescribed by their physician. Intervention group 2: It consists of a group of 15 members with aerobic exercise protocol (exercises at home, with minimal exercise equipment) which is performed for 8 weeks and 3 days a week for 1 hour. Subjects will not use any medications or dietary supplements during the eight weeks of exercise other than the medications prescribed by their physician. Investigation of changes in microRNA-192. Timepoint: Before and after the eight-week period of exercise. Method of measurement: PCR. Evaluation of changes in GLP-1 protein in serum. Timepoint: Before and after the eight-week period of exercise. Method of measurement: ELISA. Evaluation of changes in GABA protein in serum. Timepoint: Before and after the eight-week period of exercise. Method of measurement: ELISA. Evaluation of changes in Pentraxin3 protein in serum. Timepoint: Before and after the eight-week period of exercise. Method of measurement: ELISA. University of Isfahan Approved 2022-03-14 Ethics committee of Isfahan University University of Isfahan, Azadi square, Isfahan Isfahan Isfehan Iran (Islamic Republic of)