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IRCT20141209020258N170 IRCT 2021-12-18 Arak University of Medical Sciences Comparison of the effect of licorice extract, ketamine and magnesium sulfate on gargling before laryngoscopy and endotracheal intubation in the prevention of sore throat, hoarseness and cough Comparison of the effect of licorice extract, ketamine and magnesium sulfate on gargling before laryngoscopy and endotracheal intubation in the prevention of sore throat, hoarseness and cough 2022-01-05 anticipated 105 Complete https://irct.ir/trial/60639 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be allocated into 3 groups using a permuted balanced block randomization method with the size of blocks 3 and 6. Random sequence will be generated by an epidemiologist by running an online program in sealed envelope website (https://www.sealedenvelope.com/). Random chain concealment is done by opaque envelope method, Blinding description: It is a double-blind study. Analysts, evaluators, and participants are unaware of the grouping.The intern is unaware of the drugs prescribed in each group and the anesthesiologist prepares the drugs and provides them to the intern, and the patients are not aware of their group. 3 General anesthesia. Intervention 1: First intervention group: 0.5 milligram in kilogram Ketamine German company Rotex Medica, importer of Pan Pharma Therapeutic Drug Finder) with 100 milligram of lidocaine ( Caspian Tamin Rasht - Iran) and 10 milliliter of 20% dextrose (Shahid Ghazi Pharmaceutical Company - Tabriz) will gargle. Intervention 2: Second intervention group: 0.5 geram (500 milligram)licorice powder dissolved in distilled water by volume (5 millilitre) with 100 milligram lidocaine and 10 ml dextrose 20% gargle Will do. Intervention 3: Third intervention group: 2 gram of magnesium sulfate (50% made by Shahid Ghazi Pharmaceutical Company - Iran Tabriz) along with 100 milligram of lidocaine and 10 milliliter of dextrose will gargle 20%. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr Behnam Mahmodie
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 mahmodie@arakmu.ac.ir Arak University of Medical Sciences scientific Dr Hesamedin Modir
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 modir.he@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) 30 to 60 years ASA class I and II No history of sore throat before surgery No history of head and neck surgery, especially throat No history of drug use No history of chronic housing use Hypersensitivity to the drugs used in this study No upper airway infection and cold No mallampati more than 2 Lack of liver and kidney failure No need to use NG-tube during surgery and up to 24 hours after surgery The duration of surgery should not be less than 45 minutes and not more than 120 minutes 30 years 60 years Both Patient dissatisfaction to continue attending the study Observing blood during suctioning when the endotracheal tube is removed For any reason, we have to do laryngoscopy twice in the patient History of heart disease and high blood pressure T88.5 Other complications of anaesthesia Treatment - Drugs Treatment - Drugs Treatment - Drugs First intervention group: 0.5 milligram in kilogram Ketamine German company Rotex Medica, importer of Pan Pharma Therapeutic Drug Finder) with 100 milligram of lidocaine ( Caspian Tamin Rasht - Iran) and 10 milliliter of 20% dextrose (Shahid Ghazi Pharmaceutical Company - Tabriz) will gargle. Second intervention group: 0.5 geram (500 milligram)licorice powder dissolved in distilled water by volume (5 millilitre) with 100 milligram lidocaine and 10 ml dextrose 20% gargle Will do. Third intervention group: 2 gram of magnesium sulfate (50% made by Shahid Ghazi Pharmaceutical Company - Iran Tabriz) along with 100 milligram of lidocaine and 10 milliliter of dextrose will gargle 20%. Sore throat. Timepoint: In recovery, 2, 4, 8, 12 and 24 hours after surgery. Method of measurement: Visual Pain Questionnaire. Cough. Timepoint: In recovery, 2, 4, 8, 12 and 24 hours after surgery. Method of measurement: Physical examination. Hoarseness. Timepoint: In recovery, 2, 4, 8, 12 and 24 hours after surgery. Method of measurement: Physical examination. Arak University of Medical Sciences Approved 2021-09-29 Ethics comittee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)