IRCT20211214053401N1 IRCT 2022-01-02 Shiraz University of Medical Sciences ٍEffect of butyrate in ulcerative colitis Evaluation the effect of postbiotic butyrate supplementation on the expression of circadian genes, inflammation, sleep quality and psychological factors in patients with ulcerative colitis 2022-01-21 anticipated 30 Complete https://irct.ir/trial/60644 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Thirty eligible individuals are divided into 2 groups by block randomization method. The blocks are made by an out-of-study person and the assignment group is placed in a sealed envelope for each individual. After entering the study, by opening the envelope, the person will be informed of the assigned group, which are named with the letters A or B, Blinding description: In this double-blind randomized controlled trial, a person outside the study labels butyrate and placebo supplements with the letters A or B for blinding. Supplements and placebos are similar in appearance and physical properties. Assignment groups are also named based on the name assigned to the supplement and placebo. As a result, participants and researchers become blind. Also, people who evaluate the consequences and analyze the data will be blind to the groups. It should be noted that at the beginning of the study, participants are informed that they are in one of the supplement or placebo groups. 4 Ulcerative Colitis. Intervention 1: Intervention group: The patients take butyrate capsules at a dose of 600 mg once a day for 12 weeks with dietary recommendations for IBD patients that take it with the main meal. Butyrate supplement is provided by Body bio company. Intervention 2: Control group: The patients take starch capsules at a dose of 600 mg once a day for 12 weeks with dietary recommendations for IBD patients that take it with the main meal. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Its release schedule is not yet known.