IRCT20131124015510N5 IRCT 2022-05-27 Mazandaran University of Medical Sciences Evaluation of the effectiveness of two- and four-drugs regimens in eradication of H pylori Comparison of the efficacy of 14-days high dose dual therapy and 14 days concomitant regimens as first line regimen for Helicobacter pylori eradication 2022-05-22 anticipated 210 Complete https://irct.ir/trial/60656 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: ‌By using a Random Number Generator from web site of https://stattrek.com/statistics/random-number-generator.aspx , patients are randomly divided into two groups. First, I extract random numbers from the internet Equal to the number of patients to be included in the study. For example, in our study, 210 patients should be included in the study. First, a random number table is extracted from the Internet to the number of people entering the study, then, for example, number of one are assigned to the concomitant qudreple therapy group and two are assigned to the high-dose dual therapy regimen, and thus patients become random. 3 Peptic ulcer disease and H pylori infection. Intervention 1: Intervention group: In this study, patients in the intervention group used esmoprazole capsules 40 mg three times a day and amoxicillin 500 mg capsules three times a day for 14 days. Intervention 2: Control group: In the control group, patients take esmoprazole 40 mg, amoxicillin 500 mg, metronidazole 500 mg and clarithromycin 500 mg one every 12 hours for 14 days. No - There is not a plan to make this available Justification or reason for not sharing IPD is no more information.