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IRCT20141209020258N171 IRCT 2022-01-16 Arak University of Medical Sciences Comparison of the effect of labetalol and dexmedetomidine in induction of control hypotension in patients with rhinoplasty Comparison of the effect of labetalol and dexmedetomidine in induction of control hypotension in patients with rhinoplasty 2022-01-05 anticipated 64 Complete https://irct.ir/trial/60663 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be allocated into 2 groups using a permuted balanced block randomization method with the size of blocks 4 and 8. Random sequence will be generated by an epidemiologist by running an online program in sealed envelope website (https://www.sealedenvelope.com/). Random chain concealment is done by opaque envelope method, Blinding description: It is a double-blind study. Analysts, evaluators, and participants are unaware of the grouping.The intern is unaware of the drugs prescribed in each group and the anesthesiologist prepares the drugs and provides them to the intern, and the patients are not aware of their group. 3 Rhinoplasty. Intervention 1: Intervention group 1: We will infuse 0.3 milligram in kilogram in hours of labetalol during surgery. Intervention 2: Intervention group 2: We will infuse Dexmedetomidine 0.5 microgeram in kilogram in hours during surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr Behnam Mahmodie
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 mahmodie@arakmu.ac.ir Arak University of Medical Sciences scientific Dr Alireza Kamali
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 68 3222 2003 alikamaliir@yahoo.com Arak University of Medical Sciences Iran (Islamic Republic of) Age range 18 to 45 years Candidate patients for rhinoplasty surgery Body mass index 20 to 30 The duration of surgery is between 90 to 150 minutes No history of cardiovasculsar disease, pulmonary disease, renal disease and hepatic diseases No history of allergy to labetalol and dexmedetomidine No pregnancy and lactation ASA class I and II 18 years 45 years Both For any reason, they have suffered cardiorespiratory arrest during previous surgeries Treatment - Drugs Treatment - Drugs Intervention group 1: We will infuse 0.3 milligram in kilogram in hours of labetalol during surgery. Intervention group 2: We will infuse Dexmedetomidine 0.5 microgeram in kilogram in hours during surgery. Sedation. Timepoint: Recovery. Method of measurement: Ramsay score. Bleeding. Timepoint: During operation and recovery. Method of measurement: Observation,The amount of bleeding is reported on millilitre. Arak University of Medical Sciences Approved 2021-11-17 Ethics comittee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)