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IRCT20191012045067N5 IRCT 2022-01-01 Vice Chancellor for Research, Zahedan University of Medical Sciences Evaluation of effect of sumac spray on minor recurrent aphthous stomatitis treatment Evaluation of effect of sumac spray on minor recurrent aphthous stomatitis treatment 2022-01-21 anticipated 30 Complete https://irct.ir/trial/60816 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Health service research, Other design features: effectiveness of somac in the treatment of patients with recurrent aphthous stomatitis, Blinding description: patient and analyzer don't know about drugs and placebo also which one is drug and which one is placebo. N/A recurrent aphthous stomatitis. Intervention 1: Intervention group: Intervention group: People with recurrent aphthous ulcer somac spray 4 times a day for 5 days (The patient asked to use the spraay four times a day (one hour before meals and twenty minutes before bedtime) for five days and half hour after using the drug, Avoid eating and drinking. The person asked to dry the wound and then use the drug). Intervention 2: Control group: Control group: People with recurrent aphthous ulcer use placebo 4 times a day for 5 days (The patient asked to use the spray containing essence (placebo) four times a day (one hour before meals and twenty minutes before bedtime) for five days, and half hour after using the drug, Avoid eating and drinking. The person asked to dry the wound and then use the drug). Intervention 3: Intervention group: Intervention group: People with recurrent aphthous ulcer use corticosteroid 4 times a day for 5 days(The patient asked to use the orabase containing corticosteroid (triamcinolone) four times a day (one hour before meals and twenty minutes before bedtime) for five days, and half hour after using the drug, Avoid eating and drinking. The person asked to dry the wound and then use the drug). Yes - There is a plan to make this available What will be shared: manuscript When: 2 year To whom: researcher Conditions: treatment Where to obtain: internal site How to obtain: search Comments:

public Masoomeh Shirzaiy

Azadegan

Zahedan Iran (Islamic Republic of) 9817699693 +98 54 3344 1824 Shirzaiy@gmail.com Zahedan University of Medical Sciences scientific Masoomeh Shirzaiy

Azadegan

Zahedan Iran (Islamic Republic of) 9817699693 +98 54 3344 1824 Shirzaiy@gmail.com Zahedan University of Medical Sciences Iran (Islamic Republic of) The existence of 1-5 wounds less than 24h its size of less than 10mm (if there is more than one wound, the average diameter of all wounds will prevail)the pain existence in the affected area the age above 18 years lack of history of drug hypersensitivity non pregnant and no lactation Lack of history of systemic disease Lack of non-steroid anti-inflammatory medication or oral antihistamines use one month before the study entrance lack of treatment with systemic or immunosuppressive medications a month before the study entrance treatment of wounds with each drug before study entrance lack of treatment with systemic antibiotics 2weeks before the study entrance the absence of aphthea ulcer adjacent trauma ulcers caused by sharp tooth edges, broken restorative , orthodontic appliance or partial denture prosthesis 18 years no limit Both No attend of person with recurrent aphthous stomatitis in fallow up period non-controlled diabetes non-controlled hypertension pregnancy or lactation active or known infection severe mental disorder require of treatment with antibiotics during the desired treatment K12.0 Recurrent oral aphthae Treatment - Drugs Placebo Treatment - Drugs Intervention group: Intervention group: People with recurrent aphthous ulcer somac spray 4 times a day for 5 days (The patient asked to use the spraay four times a day (one hour before meals and twenty minutes before bedtime) for five days and half hour after using the drug, Avoid eating and drinking. The person asked to dry the wound and then use the drug) Control group: Control group: People with recurrent aphthous ulcer use placebo 4 times a day for 5 days (The patient asked to use the spray containing essence (placebo) four times a day (one hour before meals and twenty minutes before bedtime) for five days, and half hour after using the drug, Avoid eating and drinking. The person asked to dry the wound and then use the drug) Intervention group: Intervention group: People with recurrent aphthous ulcer use corticosteroid 4 times a day for 5 days(The patient asked to use the orabase containing corticosteroid (triamcinolone) four times a day (one hour before meals and twenty minutes before bedtime) for five days, and half hour after using the drug, Avoid eating and drinking. The person asked to dry the wound and then use the drug) Recurrent aphthous stomatitis. Timepoint: Day Zero, second, seventh after the start of treatment. Method of measurement: Visual Analogue Scale,Periodontal probe. Vice Chancellor for Research, Zahedan University of Medical Sciences Approved 2021-09-19 Ethics Committee of Zahedan University of Medical Sciences Azadegan Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)