IRCT20211220053469N1 IRCT 2021-12-29 Zahedan University of Medical Sciences The assessment of the effect of omega-3 supplementation on serum interleukin-6, alpha tumor necrosis factor and depression status in bipolar patients The assessment of the effect of omega-3 supplementation on serum interleukin-6, alpha tumor necrosis factor and depression status in bipolar patients 2022-01-27 anticipated 60 Complete https://irct.ir/trial/60849 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Randomization of patients is conducted based on permuted block stratified randomization. The patients are classed based on age and gender. The patients are randomly selected based on quadruplet blocks (two groups A & B and two replications for each group). The blocks are designed by help of R software (version of 4.02), Blinding description: Double blinding is used in the current study, so that person giving supplements and intervention, technician responsible for registration will not be informed study details. 3 Bipolar disorder. Intervention 1: Intervention group: 30 patients with bipolar disorder, in addition to their usual treatment, will receive 2 omega 3 capsules daily (made by Barij Pharmaceutical Company), each capsule containing 1 gram of omega 3, for 8 weeks, which is recommended to be taken with lunch and dinner. Intervention 2: Control group: 30 patients with bipolar disorder, in addition to their usual treatment, will receive 2 placebo capsules containing edible paraffin oil (made by Barij Pharmaceutical Company) , each capsule containing 1 gram of edible paraffin oil , for 8 weeks, which is recommended to be taken with lunch and dinner. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I need more time for making decision.