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IRCT20131203015634N3 IRCT 2022-02-27 Shahid Beheshti University of Medical Sciences Evaluation of the effect of oral sodium bicarbonate on the symptoms of overactive bladder and acidic urine Comparison of the effect of oral sodium bicarbonate and tolterodine in women with symptoms of overactive bladder and acidic urine 2022-01-20 anticipated 36 Complete https://irct.ir/trial/60909 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: According to the table of random numbers, some people are given sodium bicarbonate tablets and others are given tolterodine tablets, so that according to the random numbers table, people with even numbers of sodium bicarbonate tablets are given and people who were given individual numbers are given tolterodine tablets. The number will be 72 and there are two groups, each of which 36 people will enter, Blinding description: The two groups in the first group receive tolterodine and the second group receive sodium bicarbonate. While the tablets are packed in a white pharmacy, respectively, they will be referred to the case and control group after randomization. Patients are not aware of the type of drug given. The patient receives the first package drug and 36 patients receive the second group drug and the analysis is performed. 2-3 over active bladder. Intervention 1: Intervention group: Women with acidic urine and hyperactive bladder symptoms over 18 years of age who are randomly selected and treated with sodium bicarbonate 500 twice a day by 36 patients in the intervention group. Sodium bicarbonate tablets produced by Raha Pharmaceutical Company. Intervention 2: Control group: Control group: Women with acidic urine and symptoms of hyperactive bladder over 18 years old who are randomly selected and treated with tolterodine 1 mg twice daily in 36 patients in the control group. Tehran Daroo Pharmaceutical Company has been produced. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information
public Tayebeh Jahed Bozorgan
" SIDE OF AYATOLLAH TALEGANI HOSPITAL , SHAHID ARABI AVENUE , YAMAN AVENUE ,SHAHID CHAMRAN HIGHW
Tehran Iran (Islamic Republic of) 1185817311 +98 21 5506 6263 tayebe.jahed@sbmu.ac.ir Shahid Beheshti University of Medical Sciences scientific Tayebeh Jahed Bozorgan
47 / 5,000 Translation results "Shahid Chamran Highway, Yemen Street, Arabi Street"
Tehran Iran (Islamic Republic of) 1185817311 +98 21 5506 6263 tayebe.jahed@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Patients referred to the gynecology clinic included all patients over 18 years of age who voluntarily and knowingly complained of overactive bladder symptoms who had these symptoms for at least 12 weeks and received no treatment, had a frequency of more than 8 times and more than 2 times nocturia, urinary pH less than 6 and lacked of relaxation. Patients under 18 years of age, urinary pH more than 6, kidney stones, stress incontinence, history of abdominal menopause surgery, heart problems, urinary tract infections, malignancies, pelvic pain, neurogenic bladder , Use of antidepressants, anticholinergics, alphablockers, beta-3 agonists, and history of allergies to anticholinergics, sodium bicarbonate, rectocell, cystocell, and uterine prolapse, frequency Less than 8 and nocturia less than 2 in 24 hours are not included in the study. 18 years 80 years Female If the patient does not want to continue taking. Allergic reaction to the drug. The patient becomes pregnant. Reluctance to continue cooperation in the project. They are excluded from the study. N32.81 Overactive bladder Treatment - Drugs Treatment - Drugs Intervention group: Women with acidic urine and hyperactive bladder symptoms over 18 years of age who are randomly selected and treated with sodium bicarbonate 500 twice a day by 36 patients in the intervention group. Sodium bicarbonate tablets produced by Raha Pharmaceutical Company. Control group: Control group: Women with acidic urine and symptoms of hyperactive bladder over 18 years old who are randomly selected and treated with tolterodine 1 mg twice daily in 36 patients in the control group. Tehran Daroo Pharmaceutical Company has been produced. OVER ACTIVE BLADDER SCORE POINT. Timepoint: One month after taking the drug. Method of measurement: questionnaire OAB-V8. URINE PH. Timepoint: Before administration of tolterodine and sodium bicarbonate at the beginning of the study and one month after receiving tolterodine and sodium bicarbonate. Method of measurement: urine dipstick. Oab-v8 questionnaire score based on score before and after receiving tolterodine and sodium bicarbonate. Timepoint: Before administration of tolterodine and sodium bicarbonate at the beginning of the study and one month after receiving tolterodine and sodium bicarbonate. Method of measurement: Scoring based on the score of the questionnaire. Shahid Beheshti University of Medical Sciences Approved 2022-01-04 Ethics Committee of Shahid Beheshti University of Medical Sciences Mahdieh Hospital, Fadaiyan-e-Islam Blvd. tehran Tehran Iran (Islamic Republic of)