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IRCT20211229053561N2 IRCT 2022-01-29 Islamic Azad University of Khorasgan Branch The effect of exercise and bee propolis supplement on type 2 diabetes The effect of eight weeks of combined training (resistance-aerobic) and propolis supplementation on serum levels of adipolin (CTRP12) and secretory protein associated with secretory curvature (SFRP5) and Interleukin 6 (IL6) and glycemic indexes in women with type 2 diabetes with dyslipidemia 2022-02-04 anticipated 40 Complete https://irct.ir/trial/60930 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: In this study, subjects are randomly selected according to the law of random allocation. In this way, after determining the sample size, people will be equally divided into four groups (combined exercise + supplement, combined exercise + placebo, placebo, supplement), Blinding description: Patients in the supplement and exercise + supplement group take 3 tablets with a dose of 300 mg of propolis for eight weeks three times a day one hour after each meal. The placebo and placebo + exercise groups receive the same amount of placebo. Since the placebo and propolis supplement are placed inside the capsule in exactly the same way, participants and researchers are not aware of the type of supplement they receive. N/A Type 2 diabetes. Intervention 1: Intervention group: The first intervention group, combined training + placebo (simultaneous intervention of combined training, which includes 20 minutes of aerobic training and 45 minutes of resistance training, 3-4 sessions per week, and training for 8 weeks from low to high intensity and following the principle of extra Once done, we will take placebo pills). Intervention 2: Intervention group 2: Supplement group (3 tablets of 300 mg of bee propolis daily one hour after each meal with a glass of water and no exercise is done during the intervention period). Intervention 3: Intervention group: Combined exercise + supplement group (in this group, we will have simultaneous intervention exercise + propolis supplement, similar to the same protocol described in the previous section. Intervention 4: Control group: placebo group (this group of patients receive 3 tablets of the same shape, color and size of placebo daily and with the same protocol of the intervention group). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Fatemeh moayedi
No. 88, 25 meters from Shahid Sheikhi, South Hemmat, Moallem Square
Shiraz Iran (Islamic Republic of) ۷۱۸۵۹۹۹۱۱۵ +98 71 3632 2954 Fatemeh_m8040@yahoo.com Islamic Azad University of Khorasgan Branch scientific Fatemeh moayedi
No. 88, 25 meters from Shahid Sheikhi, South Hemmat, Moallem Square
Shiraz Iran (Islamic Republic of) ۷۱۸۵۹۹۹۱۱۵ +98 71 3632 2954 Fatemeh_m8040@yahoo.com Islamic Azad University of Khorasgan Branch Iran (Islamic Republic of) Confirmation of type 2 diabetes (fasting blood sugar greater than 126 mg / dL, oral glucose tolerance test equal to or greater than 200 mg / dL, glycosylated hemoglobin 5.6% or higher) Body mass index between 27 Up to 35, age 40 to 60 years 40 years 60 years Female Insulin use, having cardiovascular disease, musculoskeletal disease, liver disease, kidney disease, thyroid disorder, having a history of regular physical activity for at least the last six months E11 Non-insulin-dependent diabetes mellitus Treatment - Other Treatment - Other Treatment - Other Treatment - Other Intervention group: The first intervention group, combined training + placebo (simultaneous intervention of combined training, which includes 20 minutes of aerobic training and 45 minutes of resistance training, 3-4 sessions per week, and training for 8 weeks from low to high intensity and following the principle of extra Once done, we will take placebo pills). Intervention group 2: Supplement group (3 tablets of 300 mg of bee propolis daily one hour after each meal with a glass of water and no exercise is done during the intervention period). Intervention group: Combined exercise + supplement group (in this group, we will have simultaneous intervention exercise + propolis supplement, similar to the same protocol described in the previous section. Control group: placebo group (this group of patients receive 3 tablets of the same shape, color and size of placebo daily and with the same protocol of the intervention group). Interleukin 6. Timepoint: Before the intervention and 48 hours after the intervention. Method of measurement: Biochemical and laboratory methods. Adipolin. Timepoint: Before the intervention and 48 hours after the intervention. Method of measurement: Biochemical and laboratory methods. Secreted frizzled-related protein 5. Timepoint: Before the intervention and 48 hours after the intervention. Method of measurement: Biochemical and laboratory methods. Fasting blood glucose. Timepoint: Before and after the protocol. Method of measurement: Mg /dL by blood test. Triglyceride. Timepoint: Before and after the protocol. Method of measurement: Laboratory and biochemical methods. Low density lipoprotein cholesterol. Timepoint: Before and after the protocol. Method of measurement: Laboratory and biochemical methods. High-density lipoprotein cholesterol. Timepoint: Before and after the protocol. Method of measurement: Laboratory and biochemical methods. Insulin. Timepoint: Before and after the protocol. Method of measurement: Laboratory and biochemical methods. Islamic Azad University of Khorasgan Branch Approved 2021-12-22 Ethics Committee of Islamic Azad University, Khorasgan Branch University Boulevard, Arghavanieh, East J. Street Khorasgan Isfehan Iran (Islamic Republic of)