IRCT20160827029535N10 IRCT 2022-02-02 Tehran University of Medical Sciences The comparison of the efficacy of two therapeutic regimens in the treatment of gastroesophageal reflux disease in term neonates. The comparison of the efficacy of omeprazole with lansoprazole in the recovery rate of neonatal gastro esophageal reflux disease refractory to conservative therapy 2022-02-20 anticipated 120 Complete https://irct.ir/trial/60960 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: We used the random number tables from ''Rand Company'' for simple randomization that include random numbers composed of five digits and are printed in blocks of five rows . We chose a starting page in the random number table and dropped a pencil anywhere on the page to indicate a starting block in the table with eyes closed . After starting place was identified, we recorded the first three digits as we used coding system from 001 to108 for number 1 to number 108 of the patients . After that we recorded each three next digits with moving the pencil going down the column to the bottom of the page and then to the top of the next column , and so on till 108 numbers were chosen. We ignored duplicates and omitted the “ three digits “ numbers more than 108. The random numbers for coding numbers from 001 to 054 were considered as group A and the random numbers for coding numbers from 055 to108 considered as group B. According to the sample size of the study , opaque envelopes and cards were provided . Each random number was written on one opaque envelope and each card was put in one opaque envelope according to group A and B. Then the opaque envelopes were sealed and dropped into a box . According to the entrance of each participant, one of the sequentially numbered sealed envelope was opened and the group of intervention was defined, Blinding description: The participants, the medical clinician, the researcher who collect data and the who analyze the data are blind. N/A Gastroesophageal Reflux. Intervention 1: Intervention group: Intervention group1:Omeprazole 0.5mg/kg/dose /BID. Intervention 2: Intervention group: Lansoprazole 0.5mg/kg/dose /BID. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available