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IRCT20201006048950N3 IRCT 2022-01-17 Arak University of Medical Sciences The effect of alpha-adrenergic blocking drugs on reducing the excitatory symptoms of ureteral stent placement The effect of alpha-blocker drugs on reducing the irritating symptoms caused by ureteral stent placement in patients undergoing surgery 2022-04-21 anticipated 60 Complete https://irct.ir/trial/60982 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are assigned to two treatment groups through the randomized permutation block method, in which 4 blocks are used. The first group is considered A and the second group is B. Randomization list is prepared from different permutations including (AABB, BBAA, ABAB, BABA, ABBA, BAAB). Based on the randomization list, the desired treatment is assigned to patients. The first group will be given one dose of trazosine (2 mg) daily, and the second group of tamsulosin (0.4 mg) daily. These drugs are continued until the ureteral stent is removed, which is usually 4 to 6 weeks, Blinding description: This study will be performed as a double-blind clinical trial and patients who have urinary tract stones will have a ureteral stent implanted after the removal of the stone. The surgeon and the surgical method are the same for all patients under study. 2 Ureteral canal stenosis. Intervention 1: Intervention group 1: Patients are receiving trazosin drug. Intervention 2: Intervention group 2: Patients are receiving tamsulosin drug. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Mahboobeh Khosravani
Adli Alley, Meysam St., Abbas Abad St., Arak Town
Arak Iran (Islamic Republic of) 3813734197 +98 86 3224 0507 mahboobkhosravani@gmail.com Arak University of Medical Sciences scientific Mahboobeh Khosravani
Adli Alley, Meysam St., Abbas Abad St,. Arak Town
Arak Iran (Islamic Republic of) 3813734197 +98 86 3224 0507 mahboobkhosravani@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) lack of Underlying disease, especially nephrogenic cardiovascular problems, allergies, other urological diseases, urinary retention, diabetes, malignancy in the urinary tract, chronic pelvic pain syndrome, lower urinary tract symptoms No drug addiction Age less than 81 years Informed consent One-sided G stent placement no limit 81 years Both T83.122 Displacement of urinary stent Treatment - Drugs Treatment - Drugs Intervention group 1: Patients are receiving trazosin drug Intervention group 2: Patients are receiving tamsulosin drug Reduction of stent-dependent stimulus symptoms. Timepoint: Take drug:one dose daily for 4-6 weeks. Method of measurement: Questionnaires 1- Symptoms related to stent placement (USSQ) 2- International Prostate Symptoms Questionnaire (IPSS) 3- Quality of Life Questionnaire (QOL). Arak University of Medical Sciences Approved 2022-01-02 Research Ethics Committee of Arak University of Medical Sciences Adli Alley, Meysam St., Abbas Abad St., Arak Town Arak Markazi Iran (Islamic Republic of)