]>
IRCT20200516047462N4 IRCT 2022-01-15 Kashan University of Medical Sciences Effect of Chelidonium majus and hyoscyamus niger with propolis on psoriasis Evaluation of the effect of topical cream containing processes of Chelidonium majus and hyoscyamus niger with propolis on psoriasis 2022-01-15 anticipated 88 Complete https://irct.ir/trial/61195 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Samples with the help of Sealed Envelope Ltd. 2017 is divided into two groups of intervention and control in the form of blocks of 4 and 6 (selection of these blocks randomly). Each of these blocks has an equal number of control and intervention groups. A special number is assigned to each prescription drug [intervention and control (placebo)]. The doctor and the patient are not aware of the medication or placebo, and only the epidemiologist, as one of the executors, knows the number or code on registered on creams, Blinding description: A cream that has an active ingredient with a cream that does not have a substance and is used as a placebo is completely identical in terms of the shape and size of the container, and the solution themselves do not differ in terms of color, and are completely indistinguishable. The important point is that the patient is told that the topical cream used for the patient may be medication or medication. Clinicians and patients will be blinded. 3 Psoriasis. Intervention 1: Intervention group: The intervention group is included 44 patients with psoriasis. During three weeks, topical cream containing 0.5 grams of Chelidonium majus and 0.5 grams of Hyoscyamus niger with 2 grams of Propolis is used. The duration of each cream will be 6 days and the treatment will be done tree a day. The patient receives a maximum of 3 creams during the treatment period. Intervention 2: Control group: Topical cream with no active ingredients is used for three weeks. The duration of use of each cream will be 6 days. The patient receives a maximum of 3 creams during the treatment period. Yes - There is a plan to make this available What will be shared: Information about participants such as age, gender, level of education and employment will be reported. The treatment protocol and the duration of treatment process will be reported. Therapeutic results of the product and possible side effects will be reported. When: The start of the access period will be 6 months after patent presentation or 1 months after article publication. To whom: The data will be available to researchers working in academic and scientific institutes. Conditions: The data printed in the article is accessible. Where to obtain: Moderator: Morteza Kosari Email address: kosarimorteza12@gmail.com How to obtain: This access will be based on the treatment protocol in patients and treatment results, and includes effective ingredients and how to make the privacy cream of the project implementers. We will try to respond to researchers as soon as possible. Comments:
public Morteza Kosari
Kashan University of Medical Sciences, Ghotbe Ravandi Blvd
Kashan Iran (Islamic Republic of) 8715988141 +98 31 5554 2999 kosarimorteza12@gmail.com Kashan University of Medical Sciences scientific Morteza Kosari
Kashan University of Medical Sciences, Ghotbe Ravandi Blvd
Kashan Iran (Islamic Republic of) 8715988141 +98 87 1598 8141 kosarimorteza12@gmail.com Kashan University of Medical Sciences Iran (Islamic Republic of) known case of psoriasis Clinical judgment of the specialist physician based on receiving the product Patients with psoriasis during 3 months, and are in the age range of 18 to 85 years 18 years 85 years Both Existence of any history of allergy to any herbal product pregnancy for females L40 Psoriasis Treatment - Drugs Placebo Intervention group: The intervention group is included 44 patients with psoriasis. During three weeks, topical cream containing 0.5 grams of Chelidonium majus and 0.5 grams of Hyoscyamus niger with 2 grams of Propolis is used. The duration of each cream will be 6 days and the treatment will be done tree a day. The patient receives a maximum of 3 creams during the treatment period. Control group: Topical cream with no active ingredients is used for three weeks. The duration of use of each cream will be 6 days. The patient receives a maximum of 3 creams during the treatment period. PASI Score. Timepoint: At the beginning of the study, 4, 7, 14, 28 and 40 days after treatment. Method of measurement: Evaluated quantitatively and qualitatively of wounds extent and redness of the skin and the extent of involvement of different parts of the body and itching . Expression of TNF-α, IL-17 gene. Timepoint: After 40 days. Method of measurement: Real Time PCR. Kashan University of Medical Sciences Approved 2021-04-28 Ethics committee of Kashan University of Medical Sciences Ghotb Ravandi Blvd, Shahid Beheshti Hospital, University of Medical Sciences, Kashan, Iran. Kashan Isfehan Iran (Islamic Republic of)