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IRCT20220105053631N1 IRCT 2022-01-29 Islamic Azad The university of Research Sciences Branch The effect of aerobic exercise with different intensities and spirulina supplementation on ACE2 expression Comparison of the effect of high and moderate intensity aerobic exercise with spirulina supplementation on ACE2 receptor sensitivity in obese people during SARS-COVID-2 epidemic 2022-01-21 anticipated 72 Complete https://irct.ir/trial/61202 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Factorial, Purpose: Prevention, Other design features: This study is designed based on the researcher's idea and its molecular cell pathway is invented by the researcher. Increased exercise-induced irisin increases the expression of the TRIB3 gene, and increased expression of this gene causes changes in the expression of ACE2 (the main receptor of Covid 19). Therefore, reducing the expression of ACE2 as the main receptor of Covid 19 can be effective in preventing Covid 19, especially in obese people. Because obese people naturally have an increase in ACE2 expression, Randomization description: The sampling method in this study will be randomly classified. The number of samples is 72 (36 men and 36 women). Since the expression of the effect of Intervenors may be significantly different according to the sex of individuals, so in sampling we study an equal number of each sex. Also, considering that the age range of the samples in the study is between 40 and 50 years, in order to be able to make comparisons in age ranges, the categories include people aged 40 to 43 years, 44 to 47 years and 48 to 50 years in We do both groups of men and women. Based on this, we divide the sample space into 6 blocks of 12 people. Since in this study, one category belongs to the control group and five categories belong to the intervention group, so each block includes 2 members from each of these categories, which is placed in that category based on gender and age. The sealed envelop online software at https://www.sealedenvelope.com is used to randomize the sampling, Blinding description: In order to eliminate the error caused by the knowledge of the participants and the researcher about the type of treatment received and its possible effect on the research result, the study was conducted in two ways. We do blind. The placebo and the spirulina supplement are placed inside the capsule in exactly the same way, which is no different, so the participants and the researcher are not aware of the type of supplement received. 3 obesity. Intervention group: Intervention group 1: high intensity aerobic exercise; Second intervention group: moderate intensity aerobic exercise; Third intervention group; Spirulina supplementation; Fourth intervention group; High-intensity aerobic exercise with spirulina supplementation; Fifth intervention group; Moderate-intensity aerobic exercise with spirulina supplementation; Sixth intervention group; control group.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Fariba Armannia
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Tehran Iran (Islamic Republic of) 1415733868 +98 21 8145 4502 phd.armannia@gmail.com The university of Islamic Azad University, Research Sciences Branch scientific Fariba Armannia
Above Keshavarz Boulevard, Kabkanian Alley, Qazvini Alley, No. 9 Unit
Tehran Iran (Islamic Republic of) 1415733868 0098 21 814502 phd.armannia@gmail.com The univercity of Islamic Azad University of Research Sciences, Tehran Iran (Islamic Republic of) Healthy obese people 40 to 50 years without mobility restrictions 40 years 50 years Both Any type of disease including cardiovascular, diabetes, hypertension, thyroid and in general any type of acute and chronic diseases Movement restrictions E66.0 Obesity due to excess calories Prevention Intervention group: Intervention group 1: high intensity aerobic exercise; Second intervention group: moderate intensity aerobic exercise; Third intervention group; Spirulina supplementation; Fourth intervention group; High-intensity aerobic exercise with spirulina supplementation; Fifth intervention group; Moderate-intensity aerobic exercise with spirulina supplementation; Sixth intervention group; control group. Angiotensin converting enzyme 2 expression level. Timepoint: At the beginning of the study; And 8 weeks after starting spirulina supplementation and aerobic exercise. Method of measurement: reverse transcription–polymerase chain reaction. Islamic Azad The university of Research Sciences Branch Approved 2022-01-10 Islamic Azad University, North Tehran Branch Vafadar Blvd., Shahid Sadoughi St., Hakimiyeh Exit, Shahid Babaee Highway Tehran Tehran Iran (Islamic Republic of)