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IRCT20170326033146N7 IRCT 2022-01-26 Razi University The effect of Taurine on cognitive and physical function Acute effects of low and high doses of Taurine on physical and cognitive functions in 60-69 years old men 2022-02-20 anticipated 15 Complete https://irct.ir/trial/61222 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Prevention, Randomization description: Someone other than the researchers will use the random allocation software for the allocation of the subjects by a randomized blocking method. During the process of allocation, each subject will be given a unique identification code that will be given to the main researchers together with the necessary treatment (Different doses of taurine or placebo). The identification code will be used as a label to identify the group of each subject for data analysis after completion of the study. The random allocation software program can generate block randomization. The sample size and the name of the three groups (Different doses of taurine and placebo) will be defined in the randomization main menu of the software. Then, the block design will be entered as equal size. Also, the format of the unique identification code will be defined as alphanumeric with a fixed length. The last step is to generate the random list in which each entry in the list consists of a unique identification code and a group name, Blinding description: Because this study is double-blind, the subjects and researchers will not know who takes taurine or placebo, and someone else will assess the results. Also, in order not to detect different doses of taurine and placebo, they will be prepared in the same capsules and the placebo group will use maltodextrin powder. 3 . Intervention 1: Intervention group 1: First, the desired tests will be performed. Subjects will be supplemented one hour before the tests. One gram of taurine supplement will be dissolved in powder in 150 ml of water. Then the desired tests are repeated. In the first week, participants will be divided into three groups of five: one gram of taurine, six grams of taurine, and a placebo. A one-week removal period will be considered. Then in the second and third weeks, the groups will move. Intervention 2: Intervention group 2: First, the desired tests will be performed. Subjects will be supplemented one hour before the tests. Six grams of the taurine supplement will be dissolved in powder in 150 ml of water. Then the desired tests are repeated. In the first week, participants will be divided into three groups of five: one gram of taurine, six grams of taurine, and a placebo. A one-week removal period will be considered. Then in the second and third weeks, the groups will move. Intervention 3: Control group: First, the desired tests will be performed. Subjects will be supplemented one hour before the tests.1 g of maltodextrin will be dissolved in powder in 150 ml of water. Then the desired tests are repeated. In the first week, participants will be divided into three groups of five: one gram of taurine, six grams of taurine, and a placebo. A one-week removal period will be considered. Then in the second and third weeks, the groups will move. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Vahid Tadibi
School of Sports Sciences, Razi University, University Blvd., Taghe Bostan
Kermanshah Iran (Islamic Republic of) 6714414971 +98 83 3427 9265 vtadibi@yahoo.com Razi University scientific Vahid Tadibi
School of Sports Sciences, Razi University, University Blvd., Taghe Bostan
Kermanshah Iran (Islamic Republic of) 6714414971 +98 83 3427 9265 vtadibi@yahoo.com Razi University Iran (Islamic Republic of) Gender Living in SanandajAge range 60 to 69 years BMI 18 to 24 (kg / m2) Provide valid evidence of complete vaccination of COVID19 and at least three weeks after the second dose Having the desired level of physical fitness to perform tests based on the Physical Activity Readiness Questionnaire (Q-PAR) and physician approval 60 years 69 years Male Having any chronic disease Take any supplement in the two months before the start of the study Smoking Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: First, the desired tests will be performed. Subjects will be supplemented one hour before the tests. One gram of taurine supplement will be dissolved in powder in 150 ml of water. Then the desired tests are repeated. In the first week, participants will be divided into three groups of five: one gram of taurine, six grams of taurine, and a placebo. A one-week removal period will be considered. Then in the second and third weeks, the groups will move. Intervention group 2: First, the desired tests will be performed. Subjects will be supplemented one hour before the tests. Six grams of the taurine supplement will be dissolved in powder in 150 ml of water. Then the desired tests are repeated. In the first week, participants will be divided into three groups of five: one gram of taurine, six grams of taurine, and a placebo. A one-week removal period will be considered. Then in the second and third weeks, the groups will move. Control group: First, the desired tests will be performed. Subjects will be supplemented one hour before the tests.1 g of maltodextrin will be dissolved in powder in 150 ml of water. Then the desired tests are repeated. In the first week, participants will be divided into three groups of five: one gram of taurine, six grams of taurine, and a placebo. A one-week removal period will be considered. Then in the second and third weeks, the groups will move. Balance. Timepoint: At the beginning of the study and after consuming one and six grams of taurine and a placebo. Method of measurement: Balance is measured using Timed up and go test - TUG. Muscular endurance. Timepoint: At the beginning of the study and after consuming one and six grams of taurine and a placebo. Method of measurement: Muscular endurance is measured using the 30s chair stand test. Cardiorespiratory endurance. Timepoint: At the beginning of the study and after consuming one and six grams of taurine and a placebo. Method of measurement: Cardiorespiratory endurance is measured using a 6-min walk test. Cognitive function. Timepoint: At the beginning of the study and after consuming one and six grams of taurine and a placebo. Method of measurement: Cognitive function is measured using the MMSE test. Razi University Approved 2022-01-12 Ethics committee of Kermanshah Razi University Tagh-e-Bostan, University St.Razi University, Central Laboratory،Kermanshah Kermanshah Kermanshah Iran (Islamic Republic of)