IRCT20220107053652N1 IRCT 2022-11-26 Esfahan University of Medical Sciences The effect of metformin and insulin in the prevention of preeclampsia Evaluation of the effect of metformin and insulin combination therapy in comparison with the use of insulin alone in the prevention of preeclampsia in pregnant women with gestational diabetes 2022-07-23 anticipated 150 Complete https://irct.ir/trial/61403 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients are divided into two equal intervention and control groups by simple randomization method and using Rand function of Excel software. In this way, we type the expression (0,1)randbetween= in one of the cells of the Excel software, if the random number generated was 0, it is from insulin treatment alone, and if the number was observed, it was 1 from the combination treatment of metformin and insulin. We use and continue this work until all 150 patients are assigned to two intervention and control groups. N/A Pre-eclampsia. Intervention 1: Intervention group: For the intervention group, oral metformin 500 milligram twice a day and insulin will be prescribed according to the patient's needs until the delivery or termination of pregnancy. Intervention 2: Control group: For the intervention group, oral metformin 500 milligram twice a day will be prescribed until the day of delivery or termination of pregnancy. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information