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IRCT20220115053719N1 IRCT 2022-02-07 Zanjan University of Medical Sciences Tranxamic acid in cervical ectropion Comparison of the therapeutic effect of tranexamic acid with cryotherapy in the treatment of symptoms of cervical ectropion in patients referred to the gynecology clinic of Ayatollah Mousavi Hospital in Zanjan during 2022 and 2023: a randomized clinical trial study 2022-03-20 anticipated 88 Complete https://irct.ir/trial/61483 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, we will use Random number table. We will use concealment allocation, so the assigned group will be unknown. Using opaque, sealed envelopes will be assigned in a random sequence. Finally, the envelopes will be opened respectively and the assigned group of the participant will be revealed, Blinding description: Data collectors, outcome assessors, and with lessor importance Data Safety and Monitoring Board and manuscript writers will be blinded about interventions. 3 Cervical ectropion. Intervention 1: Intervention group: 500 mg Tranexamic Acid vaginal tablet daily for 10 days. Intervention 2: Control group: cryotherapy, The cryotherapy probe will be selected based on the size and location of the erosion. Cryotherapy will be performed using liquid nitrogen / carbon dioxide at zero temperature. Patients will be placed in a lithotomy position, cryotherapy will be performed by the gynecologist in charge of the project. The probe will be placed for 3 to 5 minutes. Yes - There is a plan to make this available What will be shared: the primary outcome measure would be shared . When: from 2024 To whom: people working in academic institutions Conditions: Raw data is not available to individuals and upon request, the results of the requested statistical analysis will be available to individuals. Where to obtain: Contact the research expert of the Infertility Clinic of Zanjan University to receive the required documents or data. How to obtain: To submit a request, it is enough to contact the mentioned expert and send a written and signed request to her. Comments:
public Farzane Hekmatfar
Ayatollah Mousavi hospital. Gavazang Road. Zanjan
Zanjan Iran (Islamic Republic of) 1234567 +98 915 119 6198 Hekmatfar.farzaneh@zums.ac.ir Zanjan University of Medical Sciences scientific Farzane HekmatFar
Ayatollah Mousavi hospital. Gavazang Road. Zanjan
Zanjan Iran (Islamic Republic of) 1234567 +98 915 119 6198 Hekmatfar.farzaneh@zums.ac.ir Zanjan University of Medical Sciences Iran (Islamic Republic of) Patients who have been diagnosed with cervical ectropion by an experienced gynecologist. 18 years 45 years Female Pregnancy Having any known malignancy Patients in the Menopause period Intrauterine device (IUD) Taking contraceptives in the recent 3 months N86 Erosion and ectropion of cervix uteri Treatment - Drugs Treatment - Other Intervention group: 500 mg Tranexamic Acid vaginal tablet daily for 10 days Control group: cryotherapy, The cryotherapy probe will be selected based on the size and location of the erosion. Cryotherapy will be performed using liquid nitrogen / carbon dioxide at zero temperature. Patients will be placed in a lithotomy position, cryotherapy will be performed by the gynecologist in charge of the project. The probe will be placed for 3 to 5 minutes. Pelvic pain. Timepoint: Patients' pain will be evaluated at intervals of zero, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day, the sixtieth day and the ninetieth day. Method of measurement: Visual Analogue Scale will be used to determine the pain. Zanjan University of Medical Sciences Approved 2022-01-12 Ethics Committee of Zanjan University of Medical Sciences Jomhori blvd., Azadi Sq. Zanjan Zanjan Iran (Islamic Republic of)