IRCT20220130053890N1 IRCT 2022-02-26 Iran University of Medical Sciences milrinone in persistent neonatal pulmonary hypertension Comparing the efficacy of inhaled versus infused milrinone in management of persistent pulmonary hypertension(PPHN) in infants 2022-03-01 anticipated 32 Complete https://irct.ir/trial/61634 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization with blocks, using binary blocks, Randomization of blocks using random number table. The intervention and control groups are called A and B, respectively, we prepare two series of blocks No. 1 (AB) and No. 2 (BA). Select a point in the table of random numbers at random and start moving in one direction. In each cell of the table, if the digit is an odd number, select block 1, and if it is even, selects block two, and place it in a row until 16 blocks selected (based on sample size). Then, each eligible patient who entered the study will be placed in the intervention or control group according to the order obtained, Blinding description: The patient's echocardiography is performed by a different pediatrician who is unaware of the type of treatment intervention. 3 neonatal. Intervention 1: Intervention group: treated with intravenous infusion of dopamine at a dose of 5 macro per kg body weight per minute for 3 to 5 days according to the doctor and then receive inhaled milrinone at a rate of 50 micrograms per kilogram body weight, during For 10 minutes with a frequency of twice a day. the intervention continues until the symptoms improve or the symptoms of respiratory distress or the need for oxygen increase. Intervention 2: Intervention group: Treated with intravenous infusion of dopamine at a dose of 5 macro per kg of infant weight per minute for 3 to 5 days according to the doctor's opinion and then, continuous injection of 0.3 to 0.5 micrograms per kg of body weight per minute Milrinone as a continuous intravenous infusion. the intervention continues until the symptoms improve or the symptoms of respiratory distress or the need for oxygen increase. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information