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IRCT20220203053929N1 IRCT 2022-04-20 Iran University of Medical Sciences Comparative effect of nitroglycerin and misoprostol on cervical ripening before hysteroscopy Comparative effect of nitroglycerin and misoprostol on cervical ripening before hysteroscopy 2022-04-21 anticipated 84 Complete https://irct.ir/trial/61758 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: randomization/In this study, with a sample size of 84 individuals, 42 balls for the misoprostol intervention group and 42 balls for the nitroglycerin group were placed in a lottery container and then the balls were randomly removed from the container without replacement and the sequence created was recorded, Blinding description: Outcome assessors and data analysts will not have information on how to assign groups to patients in groups A and B. We divide the outcome assessor and the patient data analyzer into A and. B know and do not know the nature of groups. 3 Cervical ripening before hysteroscopy. Intervention group: nitroglycerin is used in post fornix vaginal for cervical ripening in nuli Gravid women who are candidate for hysteroscopy. In this double-blind clinical trial on 84 women in the age range of 20 to 60 years who were randomly divided into two groups of 42 people in 6-block blocks. Two types of intervention are considered. The first intervention group (42 patients) Pearl nitroglycerin 0.4 mg in the recovery room one to half an hour before the operation up to a maximum of 3 pearls every 5 minutes with the permission of the anesthesiologist will be implanted vaginally in the posterior cervical fornix and For the second intervention group (42 patients), a misoprostol 200 microgram tablet is inserted in the posterior fornix 4 to 6 hours before surgery and the rate of cervical ipening is evaluated with calibrated dilators in both groups. The amount of bleeding and pain before surgery in two Groups are compared. Yes - There is a plan to make this available What will be shared: Comparative effect of nitroglycerin and mesoprostol in cervical ripening When: 8months To whom: Cosultant Processors Conditions: Cervical ripening before hysteroscopy /based on relative information in proposal can be conducted Where to obtain: Melika.ansarin@gmail.com How to obtain: The implementation process of the project in Rasool Akram Hospital is eight months and after that it will be published as an article Comments:
public Shahla mirgaloo bayat
No344, entrance 3 block7 phase2 Ekbatan town
Tehran Iran (Islamic Republic of) 1396813733 +98 21 4465 7764 Melika.ansarin@gmail.com Iran University of Medical Sciences scientific Shahla mirgaloo bayat
No344, entrance 3 block7 phase2 Ekbatan town
Tehran Iran (Islamic Republic of) 1396813733 +98 21 4465 7764 Melika.ansarin@gmail.com Iran University of Medical Sciences Iran (Islamic Republic of) : Conscious patient satisfaction, hysteroscopic women, lack of nitroglycerin sensitivity, without cardiovascular disease lack of existence of severe bleeding, as well as unstable status 20 years 60 years Female Systolic blood pressure less than ‌100 mm Hg, intravascular volume reduction, valvular heart disease, severe bleeding, multiparous (NVD 2 ≥ Gravid,) impossibility of using nitroglycerin based on anesthesiologist's sensitivity to any food preservative) Use of hypertension or cardiac drugs for cerebral hemorrhage, anemia, glaucoma, hyperthyroidism, heart problems, heart failure, liver and kidney disease, hypotension and dissatisfaction with continuing the company Treatment - Drugs Intervention group: nitroglycerin is used in post fornix vaginal for cervical ripening in nuli Gravid women who are candidate for hysteroscopy. In this double-blind clinical trial on 84 women in the age range of 20 to 60 years who were randomly divided into two groups of 42 people in 6-block blocks. Two types of intervention are considered. The first intervention group (42 patients) Pearl nitroglycerin 0.4 mg in the recovery room one to half an hour before the operation up to a maximum of 3 pearls every 5 minutes with the permission of the anesthesiologist will be implanted vaginally in the posterior cervical fornix and For the second intervention group (42 patients), a misoprostol 200 microgram tablet is inserted in the posterior fornix 4 to 6 hours before surgery and the rate of cervical ipening is evaluated with calibrated dilators in both groups. The amount of bleeding and pain before surgery in two Groups are compared Cervical ripening, bleeding measurment, gravidity, parity, abortion number andside Effects like vomiting, hypotension, dizziness, stomach pain, diarehea, fever. Timepoint: Before hysteroscopy and after using Medicine اand Side Effects after using. Method of measurement: Cervical dilation with measured dilator, bleeding Mount :pad percentage, pain score, weight :kg, gravidity :pregnancy count/parity:living birth delivery, sideeffect like diarehea, flushinv, hypotension, dizziness, headache, fever, nausea اند vomiting. Pain score and Mount of bleeding and dilation after hysteroscopy. Timepoint: Before hysteroscopy and after medications. Method of measurement: Pad percentage, pain score، measurment of dilation with measured dilator bouji. Iran University of Medical Sciences Approved 2022-03-26 Ethics committee of Iran University of Medical Science No344, block7, 2nd phase, Ekbatan town Tehran Tehran Iran (Islamic Republic of)