IRCT201307165665N4 IRCT 2013-10-15 Nursing and Midwifery Faculty- Vice chancellor for research Effect of Oral Cryotherapy and Normal Saline Mouth Rinse on Chemotherapy –Induced Oral Mucositis in Patients with Blood Stem-Cell Transplantation Effect of Oral Cryotherapy and Normal Saline Mouth Rinse on Chemotherapy –Induced Oral Mucositis in Patients with Autologous Blood Stem-Cell Transplantation: A Randomized clinical Trial 2013-10-06 anticipated 60 Complete https://irct.ir/trial/6180 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A oral mucositis. Intervention 1: In intervention group (ice-therapy) the small ice pieces will prepare in plastic freezer disposable formats (casts) with ready clean mineral water in dedicated refrigerator of each patient. During chemotherapy process, for cooling the oral cavity, the ice chips will place in mouth by the nurse, from 5 minutes before, during and 5 minutes after each intravenous administration of chemotherapy period continuously (mean time 20-40 Min) with considering his tolerance and with 20 minutes interval resting. The ice therapy maintains will continue based chemotherapy protocol. As the ice pieces melts it will replace with new ones. The ice pieces will prepare in a manner that would not irritate the oral cavity and could easily move in the mouth (size approximately 3*4 cm casts) will be provided in sterile containers to patients. If the participants have the prosthetic teeth, they will be asked to remove it. The usual oral care will continue after stem cell transplantation. Intervention 2: In saline rinse group, the participants will be asked to rinse their mouth by a saline solution with the room temperature (23-29 centigrade degree), 30 minutes before chemotherapy to 6 hours after it, every 30 minutes by the nurse. In this way 30-50 ml of normal saline will be used in every time. The usual oral care will continue after transplantation of stem cells.