IRCT20081019001369N8 IRCT 2022-04-14 Mashhad University of Medical Sciences Evaluation of Preventive Effect of Intravenous Trans Sodium Crocetinate on Contrast-Induced Nephropathy Evaluation of Preventive Effect of Intravenous Trans Sodium Crocetinate on Contrast-Induced Nephropathy in Patients Undergoing Coronary Angioplasty : A randomized placebo-controlled triple-blind clinical trail 2022-04-04 anticipated 152 Complete https://irct.ir/trial/61889 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: block randomization complete by using www.randomization.com. each block has 4 members defining as [AABB], [ABAB], [ABBA], [BABA], [BBAA], [BAAB]. Codes A and B are randomly assigned to the intervention groups and the control group. The aforementioned site selects 38 blocks at random from the four blocks so that 76 patients can be included in the study. patients will be assigned to one of the control groups according to the time of admission and at the beginning of admission according to the sequence obtained in the randomization stage. Interventions are allocated. These codes are not provided to the researcher present in the physician's office. Medications are also given to patient by number (A or B) and he is completely unaware of which drug or placebo is. The researcher's telephone number is also available for patients to call whenever any problem arises. (This researcher is not involved in prescribing or analyzing the data; however, he or she is solely responsible for evaluating and maintaining the codes and providing medication to patients based on a random code determined by the physician). The code assigned by him is recorded in the CRF form, Blinding description: After the codes are prepared and given to the researcher, if the inclusion criteria are met and based on the codes, the patient is randomly placed in one of the groups. The relevant code is recorded in the CRF form and the researcher considers the drug or placebo based on the assigned code for the patient. After the patient is admitted to the hospital, the patient is introduced to a nurse and the medication is prescribed by the nurse (therapist). Knows only the assigned code, performs the relevant evaluations, and after registration, the results are given to the person who performs the data analysis, in the form of a code, and the data analysis is performed without the knowledge of the data analyzer. And all confidential information is recorded and stored without mentioning the patient's name. The vials of medicine and placebo, as well as the pills taken, have a similar shape. 2 Certain current complications following acute myocardial infarction. Intervention 1: Intervention group: Patients undergoing elective angioplasty who, in addition to the standard preventive measure of CIN, recieve TSC at dose of 0.5 mg / kg as an injection, 5 minutes before angioplasty, and then on days 0 to 5 of the patient intervention in the form of oral tablets of crocetin 7.5 mg daily 3 tablets for 5 days. Intervention 2: Control group: Patients undergoing elective angioplasty who, in addition to the standard preventive measure of CIN , placebo vial containing normal saline They receive 0.9% at a dose of 0.5 mg / kg by injection 5 minutes before angioplasty, and then on days 0 to 5 of the intervention, the patient takes oral placebo tablets for 5 days, 3 tablets daily. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available