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IRCT20091012002576N26 IRCT 2022-09-13 Tehran University of Medical Sciences The effect of letrozole on endometrial thickness in endometriosis IVF parients The effect of letrozole on endometrial thickness in endometriosis parients who are candidate for IVF 2022-09-22 anticipated 80 Complete https://irct.ir/trial/62177 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization rule: First 40 letters A and 40 letters B are written on special papers that are not marked inside. Then all of them are placed in a bag and for each patient, after obtaining informed consent, a paper is removed randomly and without replacement, and based on the letter written on it, the desired intervention is performed for the patients. In addition, interventions A (case group) or B (control group) are determined by a lot, Blinding description: Patients and care providers are blinded regarding the case and control groups with using placebo that is the same as letrozole regarding form and taste. 3 Infertility. Intervention 1: Intervention group: Two tablets of letrozole 2.5 mg(Aboureihan pharmaceutical) will be used from second day of induction ovulation and continued for five days then induction continued by fixed antagonist protocol at 5th day of induction and continued till follicle 18mm wiil be occurred in TVS, endometrial thickness will be evaluated, trigger of ovulation and OPU will be scacduled for next 36 hours . Intervention 2: Control group: Two tablets of placebo will be used from second day of induction ovulation and continued for five days then induction continued by fixed antagonist protocol at 5th day of induction and continued till follicle 18mm wiil be occurred in TVS, endometrial thickness will be evaluated, trigger of ovulation and OPU will be scacduled for next 36 hours . No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Fatemeh Davari Tanha
Yas hospital, North Nejatollahi avenue, Karim Khan zand Bridge, Villa street
Tehran Iran (Islamic Republic of) 159781597878 +98 21 8880 0115 Fatedavtanha@gmail.com Tehran University of Medical Sciences scientific Fatemeh Davari Tanha
Yas hospital,North Nejatollahi avenue, Karim Khan Zand Bridge, Villa street
Tehran Iran (Islamic Republic of) 159781597878 +98 21 8880 0115 Fatedavtanha@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) IVF Candidate History of endometriosis 20 years 40 years Female pathologic lesion in endometrial cavity pathologic lesion in endometrial cavity; hypersensitivity to letrozole; liver disease liver disease N97.8 Female infertility of other origin Treatment - Drugs Treatment - Drugs Intervention group: Two tablets of letrozole 2.5 mg(Aboureihan pharmaceutical) will be used from second day of induction ovulation and continued for five days then induction continued by fixed antagonist protocol at 5th day of induction and continued till follicle 18mm wiil be occurred in TVS, endometrial thickness will be evaluated, trigger of ovulation and OPU will be scacduled for next 36 hours . Control group: Two tablets of placebo will be used from second day of induction ovulation and continued for five days then induction continued by fixed antagonist protocol at 5th day of induction and continued till follicle 18mm wiil be occurred in TVS, endometrial thickness will be evaluated, trigger of ovulation and OPU will be scacduled for next 36 hours . Endometrial thickness. Timepoint: At the day of triggering(5days after ending intervention). Method of measurement: By vaginal ultrasound. Chemical pregnancy. Timepoint: Two weeks after embryo transfer. Method of measurement: BhCG test. Clinical pregnancy. Timepoint: Four weeks after embryo transfer. Method of measurement: Visualisation fetal heart rate by vaginal ultrasound. Tehran University of Medical Sciences Approved 2022-09-11 Ethic committee of Tehran University of Medical sciences Deputy of research-6th floor-central building of Tehran University of Medical sciences-Ghods avenue-Keshavarz Blvd-Tehran-Iran Tehran Tehran Iran (Islamic Republic of)