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IRCT20211219053449N1 IRCT 2022-10-16 Mashhad University of Medical Sciences Comparison of the effects of Cetirizine and Desloratadine on the symptoms of chronic spontaneous urticarial Comparison of the effects of Cetirizine and Desloratadine on the symptoms of chronic spontaneous urticarial and quality of life 2022-10-23 anticipated 180 Complete https://irct.ir/trial/62242 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Blocked randomization. Using software and 4, 6 and 8 size blocks for hiding, the cards that identify the intervention and control group are prepared and then placed in opaque envelopes and the envelopes are arranged and numbered according to the sequence produced by the software and the patients are arranged accordingly. Admission (envelope number one for the first patient and two for the second, etc.) are assigned to the intervention or comparison group according to the card in the envelope. 2-3 Chronic urticaria. Intervention 1: Intervention group 1: prescription of cetirizine tablets from Abidi pharmaceutical company in 4 times the standard dose for 2 weeks. Intervention 2: Intervention group 2: Administration of Desloratadine tablets from Abidi pharmaceutical company in 4 times the standard dose for 2 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no further information avaible
public Maryam Khoshkhui
daneshgah str.
mashhad Iran (Islamic Republic of) 9138813944 +98 51 3840 0000 KhoshkhuiM@mums.ac.ir Mashhad University of Medical Sciences scientific maryam Khoshkhui
daneshgah str.
mashhad Iran (Islamic Republic of) 9138813944 +98 51 3840 0000 KhoshkhuiM@mums.ac.i Mashhad University of Medical Sciences Iran (Islamic Republic of) The purpose of the study will be explained to all patients and written informed consent will be obtained. CSU patients with a history of chronic spontaneous urticaria for at least six weeks during the last three months who did not respond to standard doses of second-generation antihistamines the illness was not controlled according to the disease questionnaire. 18 years 65 years Both Pregnancy Drug-induced urticaria Vasculitis urticaria Hereditary angioedema Colitis urticaria Physical urticaria cold urticaria L50 Urticaria Treatment - Drugs Treatment - Drugs Intervention group 1: prescription of cetirizine tablets from Abidi pharmaceutical company in 4 times the standard dose for 2 weeks Intervention group 2: Administration of Desloratadine tablets from Abidi pharmaceutical company in 4 times the standard dose for 2 weeks UCT questionnaire score: assessment of pruritus and urticaria symptoms. Timepoint: before and after 14 days of taking the drug. Method of measurement: UCT questionnaire. CU-QoL questionnaire: assessment of quality of life. Timepoint: At the beginning of the study and 2 weeks after taking the drug. Method of measurement: Chronic Urticaria-Quality of Life Questionnaire (CU-QoL). Dr. Abidi Pharmaceuticals Approved 2022-05-31 Research Ethics Committees of School of Medicine- Mashhad University of Medical Sciences university street mashhad Razavi Khorasan Iran (Islamic Republic of)