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IRCT20200127046282N15 IRCT 2022-05-04 Tehran University of Medical Sciences Evaluation of the effect of simultaneous injection of SVF with fractional CO2 laser in the treatment of burn scar Evaluation and comparison of the effect of simultaneous injection of Stromal Vascular Fraction with fractional CO2 laser in the treatment of burn scar 2022-04-19 anticipated 10 Complete https://irct.ir/trial/62604 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: The data analyzer will not be aware of the intervention groups (laser and SVF-laser and normal saline). Therefore, the study will be performed blindly. 1 burn scar. Intervention 1: Patients with the deka fractional CO2 laser, along with 2 cc of SVF cells, will receive three sessions one month apart. Intervention 2: Control group: Patients will receive fractional CO2 laser and physiological saline three sessions one month apart. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is -
public Sona Zare
No 4, Maryam Alley, South Kamraniyeh Street, Tehran
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2665 7438 sonazarebio@gmail.com Skin and Stem Cell Research Center, Tehran University of Medical Sciences scientific ‪Masoumeh Roohaninasab
No 4, Maryam Alley, South Kamraniyeh Street, Tehran
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2665 7438 masoomehrohani@yahoo.com Skin and Stem Cell Research Center, Tehran University of Medical Sciences Iran (Islamic Republic of) Patients with skin type 1-4 Patients with atrophic burn scars in more than one organ from 5 years ago to 3 months ago 18 years 50 years Both Age under 18 years Patients who have received laser treatment in the last three months Patients with active colloidal scar or active skin lesion at the injection site Patients with coagulation and platelet disorders Patients with a history of underlying disease such as diabetes and autoimmune connective tissue disease that affect wound healing Patients with active viral infections Patients with a history of anticoagulants History of malignancy or receiving chemotherapy Pregnancy and lactation L90 Atrophic disorders of skin Treatment - Other Treatment - Other Patients with the deka fractional CO2 laser, along with 2 cc of SVF cells, will receive three sessions one month apart. Control group: Patients will receive fractional CO2 laser and physiological saline three sessions one month apart. Scar size. Timepoint: before and 2 month after the intervention. Method of measurement: visioface. Side effects. Timepoint: One week after treatment. Method of measurement: Questionnaire and visit. Patient Satisfaction. Timepoint: Two months after treatment. Method of measurement: Questionnaire. Tehran University of Medical Sciences Approved 2021-11-10 Ethics Committee of Tehran University of Medical Sciences Tehran University of Medical Sciences, Keshavarz blvd. Tehran Tehran Iran (Islamic Republic of)