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IRCT20220324054348N1 IRCT 2022-05-09 The University of Hakim Sabzevari The effect of Pilates exercise on the treatment of multiple sclerosis The effect of eight weeks Home-Based and Outdoor Pilates Training on Neurofilament light chain, Kynurenine pathway, serum vitamin D, physical function and some psychological factors in women with multiple sclerosis 2022-02-09 anticipated 44 Complete https://irct.ir/trial/62634 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Health service research, Other design features: Among the reasons for this study is the role of home-based exercise in preventing the risk of Covid 19 in sports venues, the benefits of Pilates training and its ability to perform and adjust its intensity at home, its low cost and popularity among these patients, and its impact on improving the condition. Functional and psychological of these patients and, most importantly, considering the role of sunlight in the absorption of vitamin D and its effect on disease severity and modulation of psychological factors, it is not yet clear whether exercise through the kynurenine pathway or through other mediators can affect the results. Whether it has a psychological effect or not (Lim et al., 2021). Therefore, according to studies conducted so far, no research has been observed on the effect of Pilates exercise at home and outdoors on the structural proteins of neurons and important molecular pathways in the progression of the disease and psychological and physical factors in patients with MS. Therefore, this study is the first study to compare the effect of 8 weeks of Pilates training at home and outdoors on NFL indices, kynurenine pathway (KYN, TRP, KA, QA), serum vitamin D, and some psychological factors (fatigue, depression, quality of life). And physical function (coordination, balance, abdominal muscle endurance, gait endurance, and upper and lower body muscle strength) of women with MS. N/A multiple sclerosis. Intervention 1: Intervention group1: Pilates Exercise Group Outdoors Intervention.15 people performed an exercise program for eight weeks (three sessions per week, each session one hour). The exercise consisted of three parts: warming up, the main body of the exercise, and cooling down. The subjects had to perform 7, 14, and 9 Pilates movements in each section, respectively. Intervention 2: Intervention group2: group. Pilates practice at home. 15 people performed an exercise program for eight weeks (three sessions per week, each session one hour). The exercise consisted of three parts: warming up, the main body of the exercise, and cooling down. The subjects had to perform 7, 14, and 9 Pilates movements in each section, respectively. Intervention 3: Control group: 14 people participated in the study for eight weeks and did not run any exercise program. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information
public Dr Roya askari
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Darab Iran (Islamic Republic of) 9617976487 +98 51 4401 2763 r.askari@hsu.ac.ir The University Of Hakim Sabzevari scientific Faranak Balaghi Inaloo
NO 612 Bargh street, Kheybar Alley
Darab Iran (Islamic Republic of) 9617976487 +98 71 5352 4843 faranakbalaghi70@gmail.com The University of Hakim Sabzevari Iran (Islamic Republic of) at least two years of history EDSS between 2 and 5 no smoking, no regular exercise 25 years 40 years Female Muscle injuries Severe relapse of the disease disability to perform sports exercises Lack of regular participation in the training protocol Participate in a training program other than the research training protocol, Pregnancy relapse of MS in the last 12 weeks Change in MS medication or steroid treatment in the last 12 weeks and period of practice Lack of cooperation until the end of the research process G35 Multiple sclerosis Diagnosis Diagnosis Diagnosis Intervention group1: Pilates Exercise Group Outdoors Intervention.15 people performed an exercise program for eight weeks (three sessions per week, each session one hour). The exercise consisted of three parts: warming up, the main body of the exercise, and cooling down. The subjects had to perform 7, 14, and 9 Pilates movements in each section, respectively. Intervention group2: group. Pilates practice at home. 15 people performed an exercise program for eight weeks (three sessions per week, each session one hour). The exercise consisted of three parts: warming up, the main body of the exercise, and cooling down. The subjects had to perform 7, 14, and 9 Pilates movements in each section, respectively. Control group: 14 people participated in the study for eight weeks and did not run any exercise program. Blood serum vitamin D status. Timepoint: 48 hours before and 48 hours after the intervention. Method of measurement: enzyme-linked immunosorbent assay (ELISA) by the Kit. The inflammatory status of axonal damage (Neurofilament light chain). Timepoint: 2 days before the intervention and 2 days after the intervention. Method of measurement: enzyme-linked immunosorbent assay (ELISA) by the Kit. Status of neuroprotective metabolites in the kynurenine pathway (kynurenine and kynurenic acid). Timepoint: 48 hours before and 48 hours after the intervention. Method of measurement: Liquid chromatography–mass spectrometry (LC–MS). Status of neurodegenerative metabolite in the kynurenine pathway (quinolinic acid). Timepoint: 48 hours before and 48 hours after the intervention. Method of measurement: Liquid chromatography–mass spectrometry (LC–MS). Assess fatigue status. Timepoint: Before the intervention and 2 days after the intervention. Method of measurement: By the Fatigue Severity Scale (FSS) Questionnaire. Evaluation of Quality of life. Timepoint: 48 hours before and 48 hours after the study. Method of measurement: By multiple sclerosis Quality of life-54 (MSQOL-54) Questionnaire. Evaluation of deppresion. Timepoint: 48 hours before and 48 hours after the study. Method of measurement: questionnaires Depression, Anxiety, Stress Scales (DASS-21). Physical function based on 6 minutes walking time. Timepoint: 48 hours before and 48 hours after the study. Method of measurement: Measurement of physical function (cardiorespiratory endurance) by 6-minute walking test. The University of Hakim Sabzevari Approved 2021-10-16 Ethics Committee in Research, Hakim Sabzevari University Tohid Town sabzevar Razavi Khorasan Iran (Islamic Republic of)