IRCT20220401054389N1 IRCT 2022-05-24 Mashhad University of Medical Sciences ٍٍEffect of two method surfactant administration on preterm neonates with respiratory distress syndrome Comparison the effect of two method surfactant administration: Minimally invasive surfactant therapy)MIST) versus InSurE (Intubation, surfactant administration and extubation) in preterm neonates with respiratory distress syndrome: A randomized controlled trial 2022-04-21 anticipated 180 Complete https://irct.ir/trial/62707 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, Block randomization random allocation will be used as a reliable randomization method that leads to a balanced allocation of individuals in treatment groups at the end of each block. For this purpose, a list of random blocks is prepared using Random Allocation Software. Then according to the order of the contents of the blocks, which includes the group name and patient number, each patient is assigned to one of the groups, Blinding description: Upon the neonate's visit, the nurse accidentally opens one of the blocks, without knowing the allocations, presents one of the numbers to the neonatal fellowship, which is aware of the group type. It will be evolutionarily followed up in 4 times by a resident who does not know the allocation. Data registration in SPSS is done as groups A and B and the data analyzer does not know the intervention or control group. The follower and analyzer is not aware of the group. 3 respiratory distress syndrome. Intervention 1: Intervention group: Minimally invasive surfactant therapy(MIST). Intervention 2: Control group: Intubation (INSURE (Intubation, surfactant administration and extubation)). No - There is not a plan to make this available Justification or reason for not sharing IPD is The research team has no plans to publish the IPD