IRCT20141001019359N17 IRCT 2023-04-19 Bojnourd University of Medical Sciences Comparison of the effectiveness of Pregabalin with Pregabalin-Paracetamol on postoperative pain Comparison of the effectiveness of Pregabalin with Pregabalin-Paracetamol on postoperative pain Lumbar discectomy surgery; A Randomized clinical trial 2023-03-07 anticipated 60 Complete https://irct.ir/trial/62817 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: Double-Blind randomized clinical trial, Phase 3 on 60 patients, Web-Based randomization software was used for randomization, Randomization description: Sampling in this study will be that first in order to enter the study patients will be in the form of non-random sampling of the type "available" and then divide them into three groups by randomly assigned blocking using a web-based system. Random blocking at www.randomization.com will be done in 15 blocks of 4. So that in each block, there are 2 people in the first group (A), two people in the second group (B). After a random sequence was identified in all blocks, cards were written by writing A and B to indicate which group each patient was assigned to, and by someone other than the research team from 1 to 60 in all blocks, respectively. They are numbered and these cards are placed in sealed non-transparent envelopes, respectively. Then, in order to hide the random allocation, when the patient visits, the opaque sealed envelope will be opened and then one by one, it will be determined for each sample of the relevant group, Blinding description: None of the participants in the study will be aware of the randomization list and also to apply allocation concealment randomization, the groups are placed in closed envelopes in the admission section and eligible individuals who enter the study are included respectively. In this study, there is a placebo (normal saline) for paracetamol, patients don't know whether it is paracetamol or a placebo. Also, the clinical caregiver and the person evaluating the outcome are also aware of the interventions, but they don't know about patient's allocation. Thus, the patient, clinical caregiver, evaluator and data analyst are blinded to the study groups. 3 Pain. Intervention 1: Intervention group1 : The intervention will be one hour before the operation, receive a single dose of 300 mg Pregabalin orally and 100 cc of 0.9% normal saline by infusion 30 minutes before surgery. Intervention 2: Intervention group 2: The intervention will be that one hour before the operation, they receive a single dose of Pregabalin 300 mg orally and receive 1 gram of Paracetamol per 100 cc of normal saline 0.9% diluted by infusion 30 minutes before the end of the surgery. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information