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IRCT201102145804N2 IRCT 2011-08-12 Vice chancellor for research of Islamic Azad University, Dental Branch, Tehran Partial pulpotomy on caries free human teeth using iRootBP and White ProRoot MTA: a randomized controlled trial Partial pulpotomy on caries free human teeth using iRootBP and White ProRoot MTA: a randomized controlled trial 2011-06-20 anticipated 24 Complete https://irct.ir/trial/6289 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 pulp inflammation. Intervention 1: Intervention group: Partial pulpotomy using iRoot BP. Partial pulpotomy includes removal of 1mm of coronal pulp and covering the remaining tissue with a suitable material. Bioaggregate is the first nano particle, water based root end filling material. This product includes calcium silicate, calcium hydroxide, hydroxy apatite and Tanthalium oxide. Compared to MTA,this material lacks Bismuth oxide and calcium aluminate. iRoot BP is the injectable for of Bioaggregate (Injectable Root Bioaggregate Paste). Intervention 2: control group: partial pulpotomy using White ProRoot MTA. Partial pulpotomy includes removal of 1mm of coronal pulp and covering the remaining tissue with a suitable material.
public Mahta Fazlyab
number 4, 10th Neyestan, Pasdaran st
Tehran Iran (Islamic Republic of) 1946853314 +98 21 2275 2019 Dr.mfazlyab@gmail.com Islamic Azad University, Dental Branch, Tehran scientific Mahta Fazlyab
number 4, 10th Neyestan, Pasdaran st
Tehran Iran (Islamic Republic of) 1946853314 +98 21 2275 2019 dr.mfazlyab@gmail.com Islamic Azad University, Dental Branch, Tehran Iran (Islamic Republic of) Inclusion criteria: Patients who are assigned to extract two premolar teeth in one jaw for orthodontic treatment plan will be included; Their parents need to read and sign a fully informed form; They shouldn't have any systematic complication or take any medicine during the period of study; The teeth need to be free of any symptom, caries and decalcification; They should give a normal response to pulp sensitivity tests (cold test) compared to the control tooth on the same quadrant; The teeth need to be free of mobility or swelling in the surrounding soft tissues and any sensitivity on palpation or percussion; On radiographic examination no apical lucency or PDL widening should be detected. Exclusion criteria: Any sign of crack; filling; caries or hypocalcification on teeth will cause exclusion. Also the teeth showing apical lucency or PDL widening will be excluded; Any sensitivity to cold, heat or bite will lead to exclusion; The responses beyond the normal limits to pulp vitality testing and any medicine consumption would cause exclusion. 10 years 14 years Both K04.1 Necrosis of pulp Treatment - Drugs Treatment - Drugs Intervention group: Partial pulpotomy using iRoot BP. Partial pulpotomy includes removal of 1mm of coronal pulp and covering the remaining tissue with a suitable material. Bioaggregate is the first nano particle, water based root end filling material. This product includes calcium silicate, calcium hydroxide, hydroxy apatite and Tanthalium oxide. Compared to MTA,this material lacks Bismuth oxide and calcium aluminate. iRoot BP is the injectable for of Bioaggregate (Injectable Root Bioaggregate Paste). control group: partial pulpotomy using White ProRoot MTA. Partial pulpotomy includes removal of 1mm of coronal pulp and covering the remaining tissue with a suitable material. Dentinal bridge formation. Timepoint: six weeks after intervention. Method of measurement: microscopic evaluation. Appearance of the dentinal bridge compared to normal dentin. Timepoint: six weeks after intervention. Method of measurement: microscopic evaluation of appereance of the dentinal bridge compared to normal dentin. Thickness of the dentinal bridge compared to normal dentin. Timepoint: six weeks after intervention. Method of measurement: microscopic evaluation of thickness of the dentinal bridge compared to normal dentin. Inflammatory status of the pulp. Timepoint: six weeks after intervention. Method of measurement: microscopic evaluation : inflammatory cell count and their distribution. Vice chancellor for research of Islamic Azad University, Dental Branch, Tehran Approved 2011-06-16 Ethic committee of Islamic Azad University, Dental Branch, Tehran No 4, 10th neyestan, Pasdaran street,Tehran,Iran Tehran Iran (Islamic Republic of)