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IRCT20200926048841N2 IRCT 2022-05-16 Shahid Beheshti University of Medical Sciences Estrogen in non allergic rhinitis Effectiveness of topical esterogen on non allergic rhinitis in post menopausal women 2022-05-22 anticipated 25 Complete https://irct.ir/trial/62950 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization method. Given the block size of 2, there are two ways to assign participants to a block. AB or BA. (A) stands for topical estrogen (B) stands for no topical estrogen. Using Microsoft Excel software we produce 33 numbers equal to the sample size in each group between 0 to 10. For numbers 0, 2, 4, 6, 8, AB combination and for numbers 1, 3, 5, 7, 9, BA combination are chosen, Blinding description: The patients and physician is not aware of the patient's group; also researchers and the study statisticians were masked to treatment allocation. 3 Vasomotor rhinitis. Intervention 1: Intervention group: Take intra nasal conjugated estrogen ointment daily(50 mg containing 300 micrograms of estrogen) for 3 months. Intervention 2: Control group: They were treated with intranasal lanolin (oil used as a base for estrogen ointment)daily (50mg)for 3 months. Yes - There is a plan to make this available What will be shared: Participant data sets are to be shared When: These data files will become available one year after publication To whom: The data is only available for people working in academic institutions Conditions: The data is only available for people working in academic institutions Where to obtain: The data is obtainable from the corresponding author via email How to obtain: The data is obtainable from the corresponding author via email Comments:
public Mahboobe Asadi
Velenjak, Erabi ave.
Tehran Iran (Islamic Republic of) 1916665354 +98 21 2303 1317 mahboobeh_farvardin@yahoo.com Shahid Beheshti University of Medical Sciences scientific Mahboobe Asadi
Velenjak, Erabi ave.
Tehran Iran (Islamic Republic of) 1916665354 +98 21 2303 1317 mahboobeh_farvardin@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Menopausal women 12 months after their last menstrual bleeding Symptoms of nasal congestion (feeling of fullness in the nose, feeling of discomfort and heaviness in the nose - feeling of reduced airflow in the nose, loss of smell or mouth breathing) no limit no limit Female Use of drugs affecting the nasal airway and nasal mucosa (systemic and local) Systemic underlying diseases Previous history of rhinoplasty and sinus surgery Obstructive symptoms before menopause Presence of known sinonasal diseases, including pulpitis, chronic sinusitis, sinonasal tumors (both benign and malignant) Smoking and inhaled drugs Occupational exposure to chemical stimulants and its history Patients wاho did not have the proper cooperation for rhinomanometry, endoscopy and the use of drugs and follow-up Patients for whom estrogen use is contraindicated J30.0 Vasomotor rhinitis Treatment - Drugs Treatment - Drugs Intervention group: Take intra nasal conjugated estrogen ointment daily(50 mg containing 300 micrograms of estrogen) for 3 months. Control group: They were treated with intranasal lanolin (oil used as a base for estrogen ointment)daily (50mg)for 3 months. Effect of estrogen on rhinitis. Timepoint: Three months after treatment. Method of measurement: Rhinomanometry. Research Assistant of Shahid Beheshty University of medical sciences Approved 2021-10-23 Ethics committee of Hearing Disorders Research center of Shahid Beheshti University of Medical Si Hearing Disorders Research center, Loghman Hakim hospital, Kamali ave., South Kargar ave. Tehran Tehran Iran (Islamic Republic of)