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IRCT20160126026209N2 IRCT 2022-06-12 Esfahan University of Medical Sciences Comparative Evaluation of salivary LDH and CRP in patients Comparative Evaluation of salivary LDH and CRP in patients with oral erosive lichenoid reaction before and after systemic corticosteroid therapy 2022-05-22 anticipated 40 Complete https://irct.ir/trial/63202 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 2 Erosive lichen planus. Intervention group: the patient will be given a dose of 0.5 to 1 mg per kg prednisolone daily for seven days followed by a reduction of 5 mg each subsequent day.. Yes - There is a plan to make this available What will be shared: Not specified yet When: Not specified yet To whom: Not specified yet Conditions: Not specified yet Where to obtain: Not specified yet How to obtain: Not specified yet Comments:
public Zahra Saberi
Vice Chancellor for Research of School of Dentistry, Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 3792 5514 zahra.saberi@dnt.mui.ac.ir Esfahan University of Medical Sciences scientific Zahra Saberi
Vice Chancellor for Research of School of Dentistry, Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 3792 5514 zahra.saberi@dnt.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Suffering from oral erosive lichenoid reaction that has been definitely diagnosed by histopathologic diagnosis The patient has consent to participate in the study no limit no limit Both Presence of systemic and inflammatory disease (e.g. Covid disease, blood system malignancies, etc.) that affects study factors (LDH, CRP) The patient had been receiving former treatment for the study lesion Presence of another lesion in the patient's mouth L43.8 Other lichen planus Treatment - Drugs Intervention group: the patient will be given a dose of 0.5 to 1 mg per kg prednisolone daily for seven days followed by a reduction of 5 mg each subsequent day. The measure of salivary lactate dehydrogenase. Timepoint: measurement of lactate dehydrogenase just before the beginning of systemic treatment and 14 and 28 days after beginning the use of systemic corticosteroid. Method of measurement: Non-stimulating saliva sampling. The measure of salivary C Reactive Protein. Timepoint: measurement of C Reactive Protein just before the beginning of systemic treatment and 14 and 28 days after beginning the use of systemic corticosteroid. Method of measurement: Non-stimulating saliva sampling. Esfahan University of Medical Sciences Approved 2022-04-07 Ethics committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences School of Dentistry, St.Hezarjarib, Isfahan Isfahan Isfehan Iran (Islamic Republic of)