IRCT20200825048515N53 IRCT 2022-05-13 Esfahan University of Medical Sciences Evaluation of the effect of administration of two doses of dexmedetomidine in the prevention of chills, pain, nausea and vomiting after gallbladder surgery Evaluation of the effect of preemptive administration of two doses of dexmedetomidine in the prevention of chills, pain, nausea and vomiting after laparoscopic gallbladder surgery 2022-05-22 anticipated 75 Complete https://irct.ir/trial/63217 interventional Randomization: Not randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: In order to achieve the triple-blind study, different doses of dexmedetomidine and placebo will be prepared daily by the anesthesiologist (without the researcher's awareness) and placed in the bag and will be labeled A, B, C and will be provided daily to the researcher. Therefore, the patient, the Investigator, the person recording the clinical and basic information of the patients as well as the statistical analyst will not be aware of the type of intervention. 3 Elective surgery. Intervention 1: Intervention group 1: For patients in this group, dexmedetomidine(Elixir Pharmaceutical Company) at a dose of 0.3 ug/kg is injected as a bolus over ten minutes. Intervention 2: Second intervention group: For patients in this group, dexmedetomidine(Elixir Pharmaceutical Company) at a dose of 0.5 ug/kg is injected as a bolus over ten minutes. Intervention 3: Control group: For patients in this group, normal saline of the same volume of drugs of the previous two groups is injected intravenously, as a bolus for ten minutes. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information