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IRCT20110908007513N17 IRCT 2022-05-04 Esfahan University of Medical Sciences Comparative study of between three methods of ovulation stimulation in outcome of poor responders in ART Comparative study between three methods of ovulation stimulation, conventional, mild stimulation and combining the stop GnRH agonist with letrozole priming in outcome of poor responders in Assisted Reproductive Technology (ART) 2022-04-16 anticipated 150 Complete https://irct.ir/trial/63222 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: To start the ART cycle, patients are randomly divided into three groups. Due to the small sample size and to ensure the balance of the number of people in each group, we will use the restricted randomization method of block randomization and thus 15 out of 15 blocks including 2 Up to A, 2 to B and 2 to C will be formed, Blinding description: Patients who are eligible to enter the study are placed in one of three drug classes without the patient knowing, the results of the study after IVF are confidentially provided to a statistician for analysis. 3 Infertility. Intervention 1: Intervention group: In the control group, the traditional ovulation stimulation method is given. In the first intervention group, the low-dose gonadotropin method is given. Intervention 2: Intervention group: In the second group, the combined agonist and antagonist method is given. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no

public Ferdows mehrabian

Isfahan University of Medical Sciences, Hezar jarib Ave., Isfahan

Isfshsn Iran (Islamic Republic of) 73461-81746. +98 913 113 4081 mehrabian@med.mui.ac.ir Esfahan University of Medical Sciences scientific Ferdows mehrabian

Isfahan University of Medical Sciences, Hezar jarib Ave., Isfahan

Isfaahan Iran (Islamic Republic of) 73461-81746. +98 913 113 4081 mehrabian@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Individuals with poor ovarian response in the ovulation stimulation cycle are characterized by the POSEIDON criterion. Groups 3 and 4 are entered.The third group of patients are under 35 years with abnormal ovarian reserve test AFC (number of antral follicles) less than 5 and antimullerian hormone less than 1.2 ng / cc. The fourth group of patients are over 35 years with abnormal ovarian reserve test AFC less than 5 And antimullerian hormone less than 1.2 ng / cc 30 years 43 years Female Patients who are infected with the coronavirus during the cycle, patients who do not respond well to the ovulation stimulation cycle and do not actually have a follicle to empty, patients who received drug incorrectly during the cycle. N97 Female infertility Treatment - Drugs Treatment - Drugs Intervention group: In the control group, the traditional ovulation stimulation method is given. In the first intervention group, the low-dose gonadotropin method is given Intervention group: In the second group, the combined agonist and antagonist method is given. Comparison of the average number of oocytes obtained and the rate of chemical pregnancy, frequency of IMPLANTATION, frequency of CILINICAL PREGNANCY, frequency of ONGOING PREGNANCY is studied in three groups. Timepoint: The time of oocyte count: after ovuum pickup, the time of positive pregnancy test: 2 weeks after embryo transfer, the time of pregnancy sac: 4 weeks after embryo transfer and the time of ongoing pregnancy rate: in 12 weeks of pregnancy. Method of measurement: Evaluation of oocyte count after ovum pickup under a microscope to evaluate pregnancy test with HCG beta titration blood test and examination of pregnancy and pregnancy sac at 12 weeks with ultrasound. Nothing. Timepoint: Nothing. Method of measurement: Nothing. Esfahan University of Medical Sciences Approved 2022-04-25 Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar jarib Ave., Isfahan Isfahan Isfehan Iran (Islamic Republic of)