IRCT20201220049774N3 IRCT 2022-05-14 Mashhad University of Medical Sciences Evaluation of the effect of curcumin-piperine supplement in septic patients Evaluation of the effect of curcumin-piperine supplement on damage indicators in septic patients admitted to the intensive care unit 2022-05-17 anticipated 66 Complete https://irct.ir/trial/63236 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Permuted blocks method using the site https://www.sealedenvelope.com with the explanation that each block has 6 components. The form of the blocks can be as follows for example: [ABAABAB], [BBABAA], [BABABA], ..... Codes A and B are randomly assigned to intervention and control groups. From all possible six blocks, the site randomly selects 11 blocks to include all the patients in the study, Blinding description: In this study, the DUE unit expert only has complete information about the type of drug received (placebo or curcumin-piperine supplement). This person plays no role in the administration, treatment evaluation, and data analysis. According to the codes, the patients who fulfill the inclusion criteria are randomly assign to one of the groups by the DUE unit expert. The pills are then given to the researchers who are unaware of the content of the codes and the tablets type, and then prescribed. The placebo pill is very similar in appearance to the curcumin-piperine pill and contains the same ingredients except the active ingredient. Therefore, it is not possible for patients and clinical caregivers to distinguish pills from each other. 3 sepsis. Intervention 1: Intervention group: 33 patients will receive curcumin-piperine supplement after diagnosis of sepsis at a dose of 5.500 mg twice daily for 7 days with antibiotic regimen. Intervention 2: Control group: 33 patients will receive placebo twice a day for 7 days with antibiotic regimen. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I have not decided yet