IRCT20220424054636N1 IRCT 2022-05-17 Tehran University of Medical Sciences Studying the Effect of prolotherapy in diabetic foot ulcer Comparing the effect of Prolotherapy with Placebo, in patients with diabetic foot ulcer 2022-05-14 anticipated 60 Complete https://irct.ir/trial/63252 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: We used the block randomization method and our randomization unit was individual. Random blocks were chosen using the site www.sealedenvelope.com. Block sizes were 4, 6, and 8 and each block had both intervention A, and B equally, Blinding description: Our study was designed triple blinded and none of the patient, study investigator and data analyzer knew the type of intervention given to the patient. The drug will be provided by someone not involved in the study so the executors will be blind about the type of treatment. N/A Diabetic foot ulcer. Intervention 1: Intervention group: injection of 1ml dextrose 10% per each cm2 of wound up to 10ml, 3 times per week, in the base and periphery of wound. Intervention 2: Control group: injection of 1ml normal saline per each cm2 of wound up to 10ml, 3 times per week, in the base and periphery of wound. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It will be available on reasonable request from the journal editor