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IRCT20090129001615N6 IRCT 2023-02-21 Esfahan University of Medical Sciences The effect of two different doses of Magnesium Sulfate on prevention of pain during Etomidate injection Comparison of two different doses of Magnesium Sulfate on the prevention of pain during Etomidate injection 2023-09-11 anticipated 90 Complete https://irct.ir/trial/63659 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Because sample volume is low and we want to figure on the balance of the number of people in each group ,We use the permuted(block) randomization method what one of types of restricted randomization method is . In this order that has been made of 15 block s of 6 consisting on 2 numbers out of 2, A numbers out of B and 2 numbers out of C, Blinding description: Blinding is done as follows: the study drugs are named by the nurse as A and B codes. Patients, researchers and data collectors are unaware of the study group. The studied drugs are injected with the same syringes in terms of volume and color, and therefore the patients will not have any information about the injected drugs. 3 Pain due to Etomidate injection. Intervention 1: Intervention group 1: injection of 750 mg of magnesium sulfate 30 seconds before the injection of etomidate. Intervention 2: Intervention group 2: injection of 1 gram of magnesium sulfate 30 seconds before the injection of etomidate. Intervention 3: Control group: injection of 1 mg of lidocaine. No - There is not a plan to make this available Justification or reason for not sharing IPD is The plan belongs to the government organization and it is not possible to share it.
public Azim Honarmand
Soffeh street
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3668 0048 honarmand@med.mui.ac.ir Esfahan University of Medical Sciences scientific Azim Honarmand
Soffeh street
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3668 0048 honarmand@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) 1. All patients who need to anesthesia With Etomidate Aged 18-65 years with ASA (American Society of Anesthesiologists) grade:1 or 2 2. No History of allergy to Magnesium 3. candidate for Elective Surgery 18 years 65 years Both 1. Patients with neuromuscular disease 2. Patients who have Difficulty Communicating 3. Myocardial Ischemia 4. Cardiac Arrhythmia 5. Seizure 6. Endocrine and Metabolic Diseases 7. Mental Disorders 8. Severe Neurological Disease 9. People without a vein in the back of the hand 10. Pregnancy 11. Liver and kidney diseases 12. Thrombophlebitis 13. Chronic pain 14. pancreatic disorders 15. Patients receiving sedative or analgesic drugs 16. Substance abusers Prevention Prevention Prevention Intervention group 1: injection of 750 mg of magnesium sulfate 30 seconds before the injection of etomidate Intervention group 2: injection of 1 gram of magnesium sulfate 30 seconds before the injection of etomidate Control group: injection of 1 mg of lidocaine Pain intensity during Etomidate injection. Timepoint: Every minute until 10 minutes after Etomidate injecting. Method of measurement: Pain intensity is evaluated with using a 4-point Likert scale including: 0=no pain, 1=mild (pain expressed in response to the patient's question and without symptoms), 2=moderate (pain expressed in response to the patient's question) can be expressed along with the symptoms of the disease or pain spontaneously without asking the patient), 3=severe (a strong facial response or a response accompanied by arm withdrawal or facial grimacing) is measured. Blood pressure. Timepoint: Every minute after Etomidate injection up to 10 minutes. Method of measurement: Pulse oximeter. Heart rate. Timepoint: Every minute after Etomidate injection up to 10 minutes. Method of measurement: Pulse oximeter. Esfahan University of Medical Sciences Approved 2022-05-15 Ethics committee of Esfahan University of Medical Sciences Soffeh street Isfahan Isfehan Iran (Islamic Republic of)