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IRCT201102235889N1 IRCT 2011-12-15 no sponsor analgesic effect of ketamine in painful ophthalmic surgery Analgesic effect of low dose- ketamine during anesthesia induction in 18-80 years pateint under surgery :Strabismus,Retinal Detachment,Keratoplasty 2010-12-22 anticipated 88 Complete https://irct.ir/trial/6366 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Condition 1: pain. Condition 2: Nausea and vomiting. Intervention 1: Intervention:ketamine,0.5mg/kg during anaesthesia induction received intravenous. Intervention 2: control:normal salin, 0.5mg/kg during anaesthesia induction received intravenous.
public Mitra Abdollahi
Islamic Azad Medical University of Najafabad,Najafabad
Esfahan Iran (Islamic Republic of) +98 983312291111 mitra.abdolahi@Gmail.com Islamic Azad Medical University of Najafabad scientific Dr. Hasanali Soltani
Unit of Anesthetic and Special Cares Group of Esfahan Medical University,Basement floor, Alzahra Hospital,Esfahan
Esfahan Iran (Islamic Republic of) +98 31 1668 5555 soltani@med.mui.ac.ir Anesthetic and Special Cares Group of Esfahan Medical University Iran (Islamic Republic of) Inclusion criteria:every women and men under surgery of Strabismus,Retinal Detachment,Keratoplasty .Exclusion criteria:every women and men under surgery of Strabismus,Retinal Detachment,Keratoplasty less than 18 years and older than 80years;have contraindication of ketamine for exp:increased ICP and IOP.Ischemic heart aneurysms.Psychiatric disease such as schizophrenia.open eye injury;addict to drugs;ASAof patient are not 1 and2;any changese in anesthetic plan that cause the use of drugs other than usual;any changese in surgical plan that cause changese in anesthetic plan;any changese in conditions of during surgery that cause changes in anesthesia drugs 18 years 80 years Both H57.1 R11 Ocular pain Nausea and vomiting Treatment - Drugs Placebo Intervention:ketamine,0.5mg/kg during anaesthesia induction received intravenous control:normal salin, 0.5mg/kg during anaesthesia induction received intravenous The intensity of pain. Timepoint: after the patient's full consciousness in recovery. Method of measurement: according on VAS(0-10). The intensity of nausea. Timepoint: after the patient's full consciousness in recovery. Method of measurement: according on VAS(0-10). Vomiting frequency. Timepoint: in recovery if there is vomiting. Method of measurement: counting vomiting frequency in recovery. Maxium of anasthetic drug. Timepoint: per 5 minutes until maxium 150microgeram per kg per minutes. Method of measurement: microgeram per kg per minutes untill reaching to 80-100% systolic BloodPressure before surgery. Maxuim of analgesic during operation. Timepoint: per 10 minutes. Method of measurement: microgeram per kg untill reaching to 80-100% systolic BloodPressure before surgery. Time interval between end of surgery till extubation. Timepoint: end of surgery till extubation. Method of measurement: Presence of spontaneous breathing of pationt with The minimum of normal tidal volume. Analgesic requirement in recovery. Timepoint: after the patient's full consciousness in recovery. Method of measurement: microgeram per kg if VAS=4.bigger than4. Period of time staying in recovery. Timepoint: when paition discharge of recovery. Method of measurement: acourding on patient's conditions of discharge in terms of minutes. The duration of surgery. Timepoint: time of starting surgery till end of surgery. Method of measurement: in terms of minutes. Mean blood pressure. Timepoint: per 5 min. Method of measurement: in terms of mmhg by blood pressure monitoring device. Pulse. Timepoint: per 5 min. Method of measurement: per minutes by pulse monitoring device. Age. Timepoint: before surgery write in Questionnaire. Method of measurement: years. Sex. Timepoint: before surgery write in Questionnaire. Method of measurement: female-male. Weight. Timepoint: before surgery write in Questionnaire. Method of measurement: kg-by Balance. Underlying disease. Timepoint: before surgery write in Questionnaire. Method of measurement: Underlying disease:have.not have. no sponsor Approved 2010-09-23 Regional Bioethics Committee in medical reaserches of Medical University of Esfahan Unit VICE-Chancellory for research and technology, Medical university of Esfahan, Esfahan Esfahan Iran (Islamic Republic of)