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IRCT20220515054855N1 IRCT 2022-09-05 Mazandaran University of Medical Sciences Effect of Colchicine on the Prevention of Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery(CABG) Effect of Colchicine on the prevention of Atrial Fibrillation after Coronary Artery Bypass Grafting surgery(CABG); a Clinical Trial Study 2022-05-20 anticipated 230 Complete https://irct.ir/trial/63672 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Random block method using rendomizer software, Blinding description: Patients in the first Group will be given 0.5 mg of Colchicine every 12 hours for 48 hours before surgery, and 0.5 mg daily if they weigh less than 70 kg until discharge. Patients in the second Group will be given a Placebo similar to the conditions in the first group. Therapists and Evaluators will not be informed of the assignment of Individuals to study Groups, and the type of medication prescribed. Setting for assigning Individuals to Study Groups will be with the Project Epidemiologist. 3 Atrial Fibrillation. Intervention 1: Intervention group: Patients in the intervention group will be given orally 0.5 mg of colchicine every 12 hours 48 hours before surgery, and 0.5 mg daily until discharge if they weigh less than 70 kg. The patients will be monitored during hospitalization and if any Atrial fibrillation or its absence and the duration of hospitalization are recorded in the patient's checklist. Intervention 2: Control group: Patients in the control group will be given a placebo similar to the conditions of the intervention group. Patients are monitored during hospitalization, and if atrial fibrillation occurs or not, and the duration of hospitalization is recorded in the patient checklist. Yes - There is a plan to make this available What will be shared: All data can be shared When: after publishement To whom: every one Conditions: without roules Where to obtain: Publisher Magazine Website How to obtain: search Comments:
public Babak Bagheri
Fatemeh zahra Hospital., Municipality Squar., Artesh blvd., Sari Town
Sari Iran (Islamic Republic of) 4818813371 +98 11 48 33323023 bbagheri@gmail.com Mazandaran University of Medical Sciences scientific Babak Bagheri
Fatemeh Zahra Hospital., Municipality Square., Artesh blvd., Sari Town
Sari Iran (Islamic Republic of) 4818813371 0098 11 3323023 bbagheri@mazums.ac.ir Mazandaran University of Medical Sciences Iran (Islamic Republic of) All patients with coronary artery disease who are candidates for coronary artery bypass graft surgery. no limit 80 years Both I00-I99 بیماری های قلب و عروق Treatment - Drugs Placebo Intervention group: Patients in the intervention group will be given orally 0.5 mg of colchicine every 12 hours 48 hours before surgery, and 0.5 mg daily until discharge if they weigh less than 70 kg. The patients will be monitored during hospitalization and if any Atrial fibrillation or its absence and the duration of hospitalization are recorded in the patient's checklist. Control group: Patients in the control group will be given a placebo similar to the conditions of the intervention group. Patients are monitored during hospitalization, and if atrial fibrillation occurs or not, and the duration of hospitalization is recorded in the patient checklist. Atrial fibrilation. Timepoint: Monitoring until discharge. Method of measurement: monitiring in icu. Duration of hospitalization. Timepoint: From CABG surgery to hospital discharge. Method of measurement: monitoring. Mazandaran University of Medical Sciences Approved 2022-04-24 Ethics Committee Of Mazandaran University Of Medical Sciences Municipality Square., Army Blvd., Next To The Blood Transfusion Organization Sari Mazandaran Iran (Islamic Republic of)