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IRCT20180227038892N2 IRCT 2022-06-17 Iran University of Medical Sciences Effect of low-dose aspirin on uterine artery doppler flow in pregnant women with intrauterine growth retardation Effect of low-dose aspirin on uterine artery doppler flow in pregnant women with intrauterine growth retardation 2022-06-20 anticipated 90 Complete https://irct.ir/trial/63679 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: The outcome assessor and data analyst will not know how the groups are assigned and the study is double-blind. The person who follows the outcome of the disease in patients and the statistician who analyzes the data do not know what medication the patient has received. 3 Doppler improvements of the umbilical artery and midbrain. Intervention 1: Intervention group: Pregnant women with fetuses below 10% will be treated with 80 mg of aspirin and will have another Doppler ultrasound two weeks later. If Doppler ultrasound findings improve, the 80 mg dose will be continued until the end of pregnancy. If there is no improvement in the ultrasound findings of the uterine, umbilical and middle cerebral arteries in the same test group, the aspirin dose will be increased to 150 mg and Doppler ultrasound will be performed again two weeks later. Patients in the experimental group will receive doses of aspirin (80 or 150) until the 36th week of pregnancy. Intervention 2: Control group: Mothers with fetuses below the 10% percentile will not receive them without any intervention. Yes - There is a plan to make this available What will be shared: Part of data like the main outcome or the same will be shared When: Access after 6 months after publication To whom: Data will be available for all researchers Conditions: It can be used for further research and improvement of surgery. Surgeons and gynecologists can use this data. Where to obtain: For receiving data please be contacted with nedahashemi1363@yahoo.com How to obtain: limitless Comments:
public Neda Hashemi
Hazrat Rasool Akram Hospital-Sattar Khan-Tehran-Iran
Tehran Iran (Islamic Republic of) ۱۴۴۹۶۱۴۵۳۵ +98 21 6650 9283 nedahashemi1363@yahoo.com Iran University of Medical Sciences scientific Neda Hashemi
Rasool-e Akram Hospital, Niayesh St., Sttarkhan St., Tehran, Iran
Tehran Iran (Islamic Republic of) ۱۴۴۹۶۱۴۵۳۵ +98 21 6650 9283 nedahashemi1363@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) The mother should be less than 40 years old. The mother should not have an underlying disease (hypertension, lupus, diabetes, etc.). Have a singleton pregnancy. .... not in pregnancy. Do not have preeclampsia and hypertension. Limit intrauterine growth before 34 weeks. 18 years 40 years Female - Lack of cooperation of patients to perform serial ultrasounds lack of regular use of aspirin will be the reluctance of women to continue the study. P05.9 Newborn affected by slow intrauterine growth, unspecified Diagnosis Diagnosis Intervention group: Pregnant women with fetuses below 10% will be treated with 80 mg of aspirin and will have another Doppler ultrasound two weeks later. If Doppler ultrasound findings improve, the 80 mg dose will be continued until the end of pregnancy. If there is no improvement in the ultrasound findings of the uterine, umbilical and middle cerebral arteries in the same test group, the aspirin dose will be increased to 150 mg and Doppler ultrasound will be performed again two weeks later. Patients in the experimental group will receive doses of aspirin (80 or 150) until the 36th week of pregnancy. Control group: Mothers with fetuses below the 10% percentile will not receive them without any intervention. Doppler improvements of the umbilical artery and midbrain. Timepoint: Follow-up at the end of pregnancy and undergo Doppler ultrasound at 36 weeks of gestation. Method of measurement: Doppler ultrasound. Iran University of Medical Sciences Approved 2022-02-05 Ethics committee of Iran University of Medical Sciences Hazrat Rasool Akram Hospital-Sattar Khan Tehran Tehran Iran (Islamic Republic of)