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IRCT20200128046288N6 IRCT 2022-06-25 Ahvaz University of Medical Sciences Formulation and clinical evaluation of the brightening effect of Licorice and Cidr mask on the skin Clinical evaluation of the brightening effect of Licorice (Glycyrrhiza glabra) and Cidr (Ziziphus spina-christi) mask on the skin in young people volunteering: The double-blind, randomized, placebo-controlled trial 2022-05-26 anticipated 48 Complete https://irct.ir/trial/63716 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization of patients is done using random numbers generated by the computer and Mini-tab software by Random data option. In this way, the people under study are numbered from 1 to 48 and then the software selects 24 random numbers from 1 to 24. These random numbers will be the number of people receiving tubes containing the mask, and 24 other patients receiving tubes containing placebo, Blinding description: In this study, the placebo mask (which is completely similar to the original mask in terms of color and smell) and the main mask are coded and labeled A or B by a third party (who does not participate in the study). The subjects and the researcher only know the mask code and do not know the type of mask.The placebo mask is quite similar to the original mask in terms of color, smell and tube shape. Evaluation and analysis of data is done by the researcher. N/A Skin hyperpigmentation. Intervention 1: Intervention group: Peel off face mask of 12.6% Licorice extract and 5% Cidr extract will be made by the researchers of the present project and based on reliable sources. The mask is applied to the skin twice a week for 15 minutes and then washed off. This product was used for two months. Intervention 2: Control group: The placebo mask will be made by the researchers of the present project and based on reliable sources. The mask is applied to the skin twice a week for 15 minutes and then washed off. This product was used for two months. Yes - There is a plan to make this available What will be shared: Deidentified individual participant data of study, study protocol, statistical analysis plan, informed consent form, clinical study report, analytic code, data dictionary will be shared after the study. When: The access time is up to 6 months after the results are published To whom: Six months after the publication of articles from this study, the data obtained will be made available to the applicant researchers for further analysis Conditions: Six months after the publication of articles from this study, the data obtained will be made available to the applicant researchers for further analysis. Where to obtain: Applicants can email the responsible author to receive the requested data golfakhrabadi@yahoo.com How to obtain: Applicants will have access to the data from the present study by emailing the responsible author for up to one month. golfakhrabadi@yahoo.com Comments:
public Fereshteh Golfakhrabadi
Ahvaz Jundishapur University of Medical Sciences, Golestan street
Ahvaz Iran (Islamic Republic of) 6135733184 +98 61 3373 8378 golfakhrabadi@yahoo.com Ahvaz University of Medical Sciences scientific Fereshteh Golfakhrabadi
Ahvaz Jundishapur University of Medical Sciences, Golestan street
Ahvaz Iran (Islamic Republic of) 6135733184 +98 61 3373 8378 golfakhrabadi@yahoo.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) All people who have anykind of hyper-pigmentation (acne spot- sunspot -...) with any degree. Willingness to participate in the study and signing the consent form 18 years 50 years Female Pregnancy Breastfeeding Treatment with hormonal drugs and oral contraceptives Infection or skin disease at the study site Use of other lightening products in the last 6 months Inability to attend monthly visits L81.4 Other melanin hyperpigmentation Treatment - Drugs Placebo Intervention group: Peel off face mask of 12.6% Licorice extract and 5% Cidr extract will be made by the researchers of the present project and based on reliable sources. The mask is applied to the skin twice a week for 15 minutes and then washed off. This product was used for two months. Control group: The placebo mask will be made by the researchers of the present project and based on reliable sources. The mask is applied to the skin twice a week for 15 minutes and then washed off. This product was used for two months. Degree of skin hyperpigmentation. Timepoint: Before the intervention, the first month and the second month after using the mask. Method of measurement: Self-assessment questionnaire on the effect of the mask on the skin, photos before and after using the product. Ahvaz University of Medical Sciences Approved 2022-05-11 Ethics committee of Ahvaz Jundishapur University of Medical Sciences Ahvaz Jundishapur University of Medical Sciences,, Golestan street Ahvaz Khouzestan Iran (Islamic Republic of)