]>
IRCT201102265905N1 IRCT 2011-04-10 Eye research center,Rassoul Akram Hospital, Tehran University of Medical Sciences Effect of everyother day dosing regimen of latanoprost on intraocular pressure Intraocular Pressure Lowering Effect of 0.005% Latanoprost With Two Different Dosing Regimen 2008-07-05 anticipated 40 Complete https://irct.ir/trial/6373 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Crossover, Purpose: Treatment. N/A Glaucoma. Intervention 1: Eyedrop latanoprost 0.005% once daily at 9 PM in one eye (group 1) and every other day dose in the other eye (group 2) at month1. Intervention 2: Eyedrop latanoprost 0.005% once daily at 9 PM in one eye (group 2) and every other day dose in the other eye (group 1) at month 2.
public naveed Nilforushan
Deparment of Ophthalmology,Rassoul Akram Hospital,Niayesh St,Satarkan Ave
Tehran Iran (Islamic Republic of) +98 21 6650 9162 n-nilforushan@tums.ac.ir Eye research center,Rassoul akram Hospital Tehran University of Medical Sciences scientific Naveed Nilforushan
Ophthalmology department,Rassoul Akram Hospital, Niayesh St, Satarkan Ave
Tehran Iran (Islamic Republic of) +98 21 6650 9162 n-nilforushan@tums.ac.ir Eye research center,Rassoul Akram Hospital, Tehran University of Medical Sciences Iran (Islamic Republic of) The inclusion criteria are: Age ≥30 years, IOP ≥22 and ≤32 mmHg without any IOP lowering medication, cup to disc ratio ≤0.6, mean deviation of ≥ −6 decibel in perimetry and open angles on gonioscopy. Patients with a history of prior ocular surgery, uveitis, herpetic keratitis, and allergy to latanoprost are excluded 30 years no limit Both H40.0 , H4 Ocular Hypertension,primary open angle glaucoma Treatment - Drugs Treatment - Drugs Eyedrop latanoprost 0.005% once daily at 9 PM in one eye (group 1) and every other day dose in the other eye (group 2) at month1. Eyedrop latanoprost 0.005% once daily at 9 PM in one eye (group 2) and every other day dose in the other eye (group 1) at month 2. Intraocular pressure (IOP). Timepoint: 24 hours before instillation of latanoprost, baseline IOP was measured 3 times ,at 9AM,4PM,and 9PM and again after one and two months of drug usage,based on assigned protocol of drug instillation,were measured at the same time points. Method of measurement: Calibrated Goldmann applanation tonometer. Side effects related to drug. Timepoint: At each time visit after instillation of drug ,during 2-month period of study. Method of measurement: Anterior segment exam by slit lamp biomicroscopy,posterior segment exam by funduscopy lenses, visual acuity test by Snellen chart and patients own description of side effects like significant Itching,redness and burning sensation. Eye research center,Rassoul Akram Hospital, Tehran University of Medical Sciences Approved 2008-01-28 Tehran University of Medical Sciences Crossroads of Shahid Hemmat & Shahid Chamran Expressways Tehran- Iran 1449614535 Tehran Iran (Islamic Republic of)