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IRCT20140712018457N6 IRCT 2022-07-09 Tehran University of Medical Sciences Comparative study of the different treatment methods in size reduction of the benign thyroid nodules Comparative study of Ethanol injection, Radiofrequency Ablation, and Levothyroxine Therapy in Patients with Benign Thyroid Nodules: A Multicenter Randomized clinical Trial in Iran 2021-10-07 anticipated 90 Complete https://irct.ir/trial/64221 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: After getting familiar with the study design and obtaining the informed consent form, patients enter the intervention group (ethanol or radiofrequency therapy) or medical treatment (levothyroxine) group using block randomization method with block of 6, Blinding description: In this study, each group is given a specific name (such as A, B, and C) so that the nature of the group's treatment is unknown to the person who follows up and evaluates the results within 6 months (indeed the evaluator is blinded). N/A Benign thyroid nodule. Intervention 1: Intervention group: Patients treated with radiofrequency ablation and ethanol injection. Intervention 2: Control group: patients treated with Levothyroxine. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Mahsa Alborzi
Keshavarz Blvd
Tehran Iran (Islamic Republic of) 1419733141 +98 21 6658 1579 mahsaalborzi94@gmail.com Tehran University of Medical Sciences scientific Mahsa Alborzi Avanaki
Keshavarz Blvd
Tehran Iran (Islamic Republic of) 1419733141 +98 21 6658 1579 mahsaalborzi94@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Normal thyroid test including TSH, T۴, T۳, T۳RU, Anti TPO The nodule has grown or the patient reports pressure sign FNA biopsy specimen or core needle biopsy under ultrasound guidance is benign. Normal blood calcitonin level The patient has not received previous treatment for thyroid nodules 18 years 65 years Both Malignant sonographic features of thyroid nodules Malignant or non-diagnostic lesions in pathology results Pregnancy Abnormal thyroid function tests or abnormal calcitonin E04.1 Nontoxic single thyroid nodule Treatment - Other Treatment - Other Intervention group: Patients treated with radiofrequency ablation and ethanol injection Control group: patients treated with Levothyroxine Size of thyroid nodule. Timepoint: one, three and six month following related treatment. Method of measurement: Measurement of thyroid nodules size using ultrasound based on millimeters. Tehran University of Medical Sciences Approved 2021-10-06 Imam Khomeini Hospital Medical Ethics Committee Keshavarz Blvd Tehran Tehran Iran (Islamic Republic of)