IRCT20220425054653N1 IRCT 2022-09-11 Islamic Azad University The effect of probiotic supplementation on obesity Assessment of the effects of Probiotic supplementation on body mass index in overweight and obese adults 2022-09-13 anticipated 74 Complete https://irct.ir/trial/64371 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: It will be done with simple random method using the lottery. For each patient, a number or code is provided, then the numbers will be written on pieces of paper. The pieces of paper are placed in a container and well stirred, and the sample is selected according to the sample size, Blinding description: Prior to the beginning of the study, the canisters containing the capsules are coded by individuals other than the research team, A and B, so that the knowledge of the type of capsules received by each group is not known to the researcher. Since this study is double blind, the subjects , the researchers have no information about the individuals located in the studied and control groups. 3 Overweight and Obesity. Intervention 1: Intervention group: Daily intake of a probiotic capsule containing (Lactobacillus rhamnosus, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium lactis, Bifidobacterium brouh, Bifidobacterium longum, Bifidobacterium bifidum, Streptococcus thermophilus,10^9 cfu), for 12 week, Production company: Danesh Bonyan Zist Takhmir. Intervention 2: Control group: A daily placebo capsule with appearance characteristics including shape, color, smell, and taste completely similar to a probiotic capsule without microorganisms, for 12 weeks, Production company: Danesh Bonyan Zist Takhmir. No - There is not a plan to make this available Justification or reason for not sharing IPD is Due to ethical issues