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IRCT20220316054314N1 IRCT 2022-07-08 Tabriz University of Medical Sciences Investigation of pain after implanted tooth surgery following taking pregabalin and acetaminophen Evaluation of pain after mandibular impacted third molar surgery following pregabalin and acetaminophen 2022-07-04 anticipated 32 Complete https://irct.ir/trial/64456 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The method of random sampling is among the people who refer to the maxillofacial surgery department of Faculty of Dentistry in Tabriz. The randomization method is simple and individual. Our tool for randomizing a table of random numbers. Also, the allocation of treatment to patients will be done randomly. In such a way that the type of treatment is specified with the code A (acetaminophen) and B (pregabalin) and will be placed inside the sealed envelopes; Then the envelopes will be placed in a bag and mixed. Then it will be randomly removed from the bag and after seeing the code, the treatment will be given to the patient. None of the patients will be informed about the type of treatment of another patient, Blinding description: Medicines will be coded in similar containers with A and B codes. The evaluator who will follow the patients and record their pain level and painkillers will not be aware of the type of drugs. Also, the patient is aware of the existence of two types of drugs, but they will not be aware of the type of drug in each surgery. 2 Impacted teeth. Intervention 1: Intervention group: 150 mg of pregabalin with 100 cc of water will be given to the patient one hour before the mandibular third molar extraction surgery. Up to 24 hours after surgery, the patient will record the level of pain every two hours based on the VAS on the designated table. Intervention 2: Control group: 650 mg of acetaminophen with 100 cc of water will be given to the patient one hour before the mandibular third molar extraction surgery. Up to 24 hours after surgery, the patient will record the level of pain every two hours based on the VAS on the designated table. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Farrokh Farhadi
Tabriz University of Medical Sciences, Golgasht St
Tabriz Iran (Islamic Republic of) 5166614711 +98 41 6058 3553 drfarrokhfarhadi@gmail.com Tabriz University of Medical Sciences scientific Farrokh Farhadi
Tabriz University of Medical Sciences, Golgasht St
Tabriz Iran (Islamic Republic of) 5166614711 +98 41 6058 3553 drfarrokhfarhadi@gmail.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Patients 18-35 years old Candidate for surgery on the hidden third molar of the lower jaw on both sides 18 years 35 years Both History of diabetes controlled by oral medications Using Corticosteroid History of using drug History of using chronic NSAID drugs History of chronic use of pregabalin or sedative drugs History of painkiller consumption in the last 24 hours Psychiatric disorder History of bone disease History of bilateral mandibular molar pain K01.1 Impacted teeth Treatment - Drugs Treatment - Drugs Intervention group: 150 mg of pregabalin with 100 cc of water will be given to the patient one hour before the mandibular third molar extraction surgery. Up to 24 hours after surgery, the patient will record the level of pain every two hours based on the VAS on the designated table. Control group: 650 mg of acetaminophen with 100 cc of water will be given to the patient one hour before the mandibular third molar extraction surgery. Up to 24 hours after surgery, the patient will record the level of pain every two hours based on the VAS on the designated table. The amount of pain. Timepoint: Up to 24 hours after surgery, once every two hours. Method of measurement: Visual Analogue Scale. Tabriz University of Medical Sciences Approved 2022-06-27 Ethics committee of Tabriz University of Medical Sciences 2nd Floor, Central Building No. 2,Tabriz University of Medical Sciences, Golgasht St. Tabriz East Azarbaijan Iran (Islamic Republic of)