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IRCT20130603013566N10 IRCT 2022-07-31 Vice chancellor for Research,Tabriz University Of Medical Sciences Comparison of the effect of GnRH agonist administration with GNRH antagonist protocol on assisted reproductive methods in patients with reduced ovarian response. Comparison of the effect of gonadotropin-releasing hormone GnRH agonist administration with GNRH antagonist protocol on assisted reproductive methods in patients with reduced ovarian response. 2022-08-01 anticipated 50 Complete https://irct.ir/trial/64483 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: A computer-generated randomization list with a block size of 4, with 1:1 allocation will be used to randomize patients. In such a case, one control will be checked for each intervention and with each of the 4 patients enrolled in the study, the two groups are balanced in terms of control and intervention.50 matte and sealed envelope samples will be prepared. Randomization will be performed by a non-research person and The type of intervention will be written by random allocation on paper and placed inside the envelopes.Envelopes will be numbered from number 1 to the end.The first person will be given the first envelope and this will continue until the last desired number; There will be 25 people in group 1 and 25 people in group 2, for a total of 50 people, Blinding description: In this study, the data analyst and outcome assessor will not know the type of drug. The possibility of blinding the patient and the doctor in order to respect the rights of the patients is not acceptable because it will require at least 13 painful injections under the skin with distilled water (with the same label as the drug), which is not ethically correct and has not been done in similar studies. 3 Infertility. Intervention 1: Control group: In the control group IVF-ICSI with usual GnRH antagonist protocol will be started. Intervention 2: Intervention group: In the case group, patients will receive GNRH agonists in the luteal phase of pre-IVF-ICSI cycle (0.1 milligram every day for 10 to 12 days), and then the IVF-ICSI cycle will be started with the GNRH antagonist protocol. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After the completion of the project, the decision will be made.
public Kobra Hamdi
Tabriz University Of Medical Sciences, Golgasht Street
Tabriz Iran (Islamic Republic of) 5138665793 +98 35519161 lahroudin@gmail.com Tabriz University of Medical Sciences scientific Kobra Hamdi
Tabriz University Of Medical Sciences, Golgasht Street
Tabriz Iran (Islamic Republic of) 5138665793 +98 35519161 lahroudin@gmail.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Infertile women defined as poor ovarian responders according to the Bologna criteria (presence of at least two of the three Bologna criteria) Primary infertility Age 20 to 42 20 years 42 years Female Not agreeing to participate in the study Severe oligospermia body mass index 30 and above Severe endometriosis Smoking and alcohol consumption N97 Female infertility Treatment - Drugs Treatment - Drugs Control group: In the control group IVF-ICSI with usual GnRH antagonist protocol will be started Intervention group: In the case group, patients will receive GNRH agonists in the luteal phase of pre-IVF-ICSI cycle (0.1 milligram every day for 10 to 12 days), and then the IVF-ICSI cycle will be started with the GNRH antagonist protocol. Number of eggs. Timepoint: the day of oocytes pick up. Method of measurement: Microscopic examination. Egg quality. Timepoint: The day of oocytes pick up. Method of measurement: Microscopic examination. Pregnancy. Timepoint: 7-6 weeks to see the gestational sac. Method of measurement: Ultrasound. Vice chancellor for Research,Tabriz University Of Medical Sciences Approved 2022-06-01 Ethics Committee Of Tabriz University Of Medical Sciences Third Floor; Central Building of Number2; Golgasht Street Tabriz East Azarbaijan Iran (Islamic Republic of)